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J Med Genet. 1984 August; 21(4): 286–289.
PMCID: PMC1049299

Trichothiodystrophy-neurotrichocutaneous syndrome of Pollitt: a report of two unrelated cases.


Two unrelated children presenting with mental and physical retardation and sulphur deficient brittle hair are reported. These are thought to be further cases of the autosomal recessive neurotrichocutaneous syndrome of Pollitt, of which eight cases have been previously reported.

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Selected References

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  • Coulter DL, Beals TF, Allen RJ. Neurotrichosis: hair-shaft abnormalities associated with neurological diseases. Dev Med Child Neurol. 1982 Oct;24(5):634–644. [PubMed]
  • Pollitt RJ, Jenner FA, Davies M. Sibs with mental and physical retardation and trichorrhexis nodosa with abnormal amino acid composition of the hair. Arch Dis Child. 1968 Apr;43(228):211–216. [PMC free article] [PubMed]
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  • Jorizzo JL, Atherton DJ, Crounse RG, Wells RS. Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature (IBIDS syndrome). Br J Dermatol. 1982 Jun;106(6):705–710. [PubMed]
  • Lazarides E. Intermediate filaments as mechanical integrators of cellular space. Nature. 1980 Jan 17;283(5744):249–256. [PubMed]

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