PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of brjvendisLink to Publisher's site
 
Br J Vener Dis. Dec 1984; 60(6): 364–370.
PMCID: PMC1046382
Treponema pallidum specific IgM haemagglutination test for serodiagnosis of syphilis.
T Sato, E Kubo, M Yokota, T Kayashima, and T Tomizawa
Abstract
The Treponema pallidum specific IgM haemagglutination (TP-IgM-HA) test uses erythrocytes sensitised with antiserum to human IgM to separate IgM from IgG in serum. Specific antitreponemal IgM captured in this way is detected by adding a second reagent comprising erythrocytes sensitised with T pallidum antigen. Eighty two serum samples from 82 patients with untreated syphilis, 521 samples from 73 patients with treated syphilis, and 1872 samples from people who did not have syphilis were examined by the 19S(IgM)-TPHA (T pallidum haemagglutination), IgM-FTA-ABS (fluorescent treponemal antibody absorbed), TP-IgM-ELISA (enzyme linked immunosorbent assay), and TP-IgM-HA tests for the presence of 19S(IgM) antibodies specific to treponemes. The sensitivity of the TP-IgM-HA test was 97.6% and the specificity was 99.7%. We also traced IgM specific to treponemes in untreated patients with primary syphilis by four different tests. The TP-IgM-HA test results clearly reflected the effect of the treatment.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (907K), or click on a page image below to browse page by page.
Articles from The British Journal of Venereal Diseases are provided here courtesy of
BMJ Group