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Br J Ophthalmol. 1991 November; 75(11): 693–695.
PMCID: PMC1042533

Acquired pigmentation simulating Peutz-Jeghers syndrome: initial manifestation of diffuse uveal melanocytic proliferation.


A 74-year-old man with an occult carcinoma of the colon developed pigmentation of the mouth and penis typical of the Peutz-Jeghers syndrome as the first manifestation of bilateral diffuse uveal melanocytic proliferation. The simultaneous appearance of extraocular pigmented lesion and those in the uveal tract of both eyes of this patient provides further evidence that bilateral diffuse uveal melanocytic proliferation may be caused by activation of occult melanocytic naevus cells in response to either a hormone-producing carcinoma or to some other common oncogenic stimulus.

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Selected References

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  • Ryll DL, Campbell RJ, Robertson DM, Brubaker SJ. 7. Pseudometastatic lesions of the choroid. Ophthalmology. 1980 Nov;87(11):1181–1186. [PubMed]
  • Barr CC, Zimmerman LE, Curtin VT, Font RL. Bilateral diffuse melanocytic uveal tumors associated with systemic malignant neoplasms. A recently recognized syndrome. Arch Ophthalmol. 1982 Feb;100(2):249–255. [PubMed]
  • Prause JU, Jensen OA, Eisgart F, Hansen U, Kieffer M. Bilateral diffuse malignant melanoma of the uvea associated with large cell carcinoma, giant cell type, of the lung. Case report of a newly described syndrome. Ophthalmologica. 1984;189(4):221–228. [PubMed]
  • Gass JD, Gieser RG, Wilkinson CP, Beahm DE, Pautler SE. Bilateral diffuse uveal melanocytic proliferation in patients with occult carcinoma. Arch Ophthalmol. 1990 Apr;108(4):527–533. [PubMed]
  • Thirkill CE, Roth AM, Keltner JL. Cancer-associated retinopathy. Arch Ophthalmol. 1987 Mar;105(3):372–375. [PubMed]
  • JEGHERS H, McKUSICK VA, KATZ KH. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. N Engl J Med. 1949 Dec 22;241(25):993–passim. [PubMed]
  • Reid JD. Intestinal carcinoma in the Peutz-Jeghers syndrome. JAMA. 1974 Aug 12;229(7):833–834. [PubMed]
  • Dewan PA, Hope JK. Peutz-Jeghers syndrome. Aust N Z J Surg. 1985 Dec;55(6):613–616. [PubMed]
  • Banse-Kupin LA, Douglass MC. Localization of Peutz-Jeghers macules to psoriatic plaques. Arch Dermatol. 1986 Jun;122(6):679–683. [PubMed]
  • Traboulsi EI, Maumenee IH. Periocular pigmentation in the Peutz-Jeghers syndrome. Am J Ophthalmol. 1986 Jul 15;102(1):126–127. [PubMed]
  • Jugdutt BI, Amy RW. Healing after myocardial infarction in the dog: changes in infarct hydroxyproline and topography. J Am Coll Cardiol. 1986 Jan;7(1):91–102. [PubMed]

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