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Br J Ophthalmol. 1990 June; 74(6): 325–327.
PMCID: PMC1042120

Ocular Lyme disease: case report and review of the literature.


Lyme disease is an emerging new spirochaetal disease in which ocular complications may arise. We have seen a 45-year-old woman who developed unilateral endophthalmitis leading to blindness during the course of this disease. Ocular tissue showed the characteristic spirochete. A literature review shows that the commonest ocular manifestation of Lyme disease is a mild conjunctivitis, but other symptoms may include periorbital oedema, oculomotor palsies, uveitis, papilloedema, papillitis, interstitial keratitis, and others. Ophthalmologists treating patients from Lyme disease endemic areas need to be aware of the protean clinical manifestation of this disease.

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Selected References

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  • Steere AC, Grodzicki RL, Kornblatt AN, Craft JE, Barbour AG, Burgdorfer W, Schmid GP, Johnson E, Malawista SE. The spirochetal etiology of Lyme disease. N Engl J Med. 1983 Mar 31;308(13):733–740. [PubMed]
  • Steere AC, Malawista SE, Hardin JA, Ruddy S, Askenase W, Andiman WA. Erythema chronicum migrans and Lyme arthritis. The enlarging clinical spectrum. Ann Intern Med. 1977 Jun;86(6):685–698. [PubMed]
  • Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE. The early clinical manifestations of Lyme disease. Ann Intern Med. 1983 Jul;99(1):76–82. [PubMed]
  • Schmid GP. The global distribution of Lyme disease. Rev Infect Dis. 1985 Jan-Feb;7(1):41–50. [PubMed]
  • Steere AC, Duray PH, Kauffmann DJ, Wormser GP. Unilateral blindness caused by infection with the Lyme disease spirochete, Borrelia burgdorferi. Ann Intern Med. 1985 Sep;103(3):382–384. [PubMed]
  • Eichenfield AH, Goldsmith DP, Benach JL, Ross AH, Loeb FX, Doughty RA, Athreya BH. Childhood Lyme arthritis: experience in an endemic area. J Pediatr. 1986 Nov;109(5):753–758. [PubMed]
  • Wong T. The onset of bilateral uveitis in an elderly man with fever, headache, and a rash. Ophthalmic Surg. 1989 Feb;20(2):154–156. [PubMed]
  • Winward KE, Smith JL. Ocular disease in Caribbean patients with serologic evidence of Lyme borreliosis. J Clin Neuroophthalmol. 1989 Jun;9(2):65–70. [PubMed]
  • Bialasiewicz AA, Ruprecht KW, Naumann GO, Blenk H. Bilateral diffuse choroiditis and exudative retinal detachments with evidence of Lyme disease. Am J Ophthalmol. 1988 Apr 15;105(4):419–420. [PubMed]
  • Pachner AR, Steere AC. The triad of neurologic manifestations of Lyme disease: meningitis, cranial neuritis, and radiculoneuritis. Neurology. 1985 Jan;35(1):47–53. [PubMed]
  • Reik L, Jr, Burgdorfer W, Donaldson JO. Neurologic abnormalities in Lyme disease without erythema chronicum migrans. Am J Med. 1986 Jul;81(1):73–78. [PubMed]
  • Ackermann R, Hörstrup P, Schmidt R. Tick-borne meningopolyneuritis (Garin-Bujadoux, Bannwarth). Yale J Biol Med. 1984 Jul-Aug;57(4):485–490. [PMC free article] [PubMed]
  • Reik L, Steere AC, Bartenhagen NH, Shope RE, Malawista SE. Neurologic abnormalities of Lyme disease. Medicine (Baltimore) 1979 Jul;58(4):281–294. [PubMed]
  • Raucher HS, Kaufman DM, Goldfarb J, Jacobson RI, Roseman B, Wolff RR. Pseudotumor cerebri and Lyme disease: a new association. J Pediatr. 1985 Dec;107(6):931–933. [PubMed]
  • Wu G, Lincoff H, Ellsworth RM, Haik BG. Optic disc edema and Lyme disease. Ann Ophthalmol. 1986 Aug;18(8):252–255. [PubMed]
  • Schechter SL. Lyme disease associated with optic neuropathy. Am J Med. 1986 Jul;81(1):143–145. [PubMed]
  • Bertuch AW, Rocco E, Schwartz EG. Eye findings in Lyme disease. Conn Med. 1987 Mar;51(3):151–152. [PubMed]
  • Baum J, Barza M, Weinstein P, Groden J, Aswad M. Bilateral keratitis as a manifestation of Lyme disease. Am J Ophthalmol. 1988 Jan 15;105(1):75–77. [PubMed]
  • Orlin SE, Lauffer JL. Lyme disease keratitis. Am J Ophthalmol. 1989 Jun 15;107(6):678–680. [PubMed]
  • Jacobson DM, Frens DB. Pseudotumor cerebri syndrome associated with Lyme disease. Am J Ophthalmol. 1989 Jan 15;107(1):81–82. [PubMed]
  • Aaberg TM. The expanding ophthalmologic spectrum of Lyme disease. Am J Ophthalmol. 1989 Jan 15;107(1):77–80. [PubMed]
  • Markowitz LE, Steere AC, Benach JL, Slade JD, Broome CV. Lyme disease during pregnancy. JAMA. 1986 Jun 27;255(24):3394–3396. [PubMed]
  • Clark JR, Carlson RD, Sasaki CT, Pachner AR, Steere AC. Facial paralysis in Lyme disease. Laryngoscope. 1985 Nov;95(11):1341–1345. [PubMed]
  • Schaltenbrand G. Durch Arthropoden übertragene Infektionen der Haut und des Nervensystems. Munch Med Wochenschr. 1966 Aug 12;108(32):1557–1562. [PubMed]
  • Steere AC, Pachner AR, Malawista SE. Neurologic abnormalities of Lyme disease: successful treatment with high-dose intravenous penicillin. Ann Intern Med. 1983 Dec;99(6):767–772. [PubMed]
  • Belin MW, Baltch AL, Hay PB. Secondary syphilitic uveitis. Am J Ophthalmol. 1981 Aug;92(2):210–214. [PubMed]

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