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Br J Ophthalmol. 1987 July; 71(7): 549–552.
PMCID: PMC1041224

Is there any difference in the photobiological properties of melanins isolated from human blue and brown eyes?

Abstract

Investigations were carried out to determine whether the melanin present in the blue and brown eyes were eumelanin, the melanin present in black hair and dark skin, or pheomelanin, the melanin present in red hair and the skin of people with red hair. Our results showed that UV-visible irradiation of blue or brown eye melanin did not produce any superoxide. Irradiation of 51Cr-labelled Ehrlich ascites carcinoma cells in the presence of blue or brown eye melanin did not produce significant cell lysis. The electron spin resonance (ESR) signals of blue and brown eye melanins were very similar to those of eumelanin. Comparison of these findings with our previous results indicated that the blue and brown eye melanins are essentially eumelanin. The ESR signals further suggested that in the case of both blue and brown eye melanins the iris, ciliary body, choroid, and retinal pigment epithelium did not differ.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Prota G, Thomson RH. Melanin pigmentation in mammals. Endeavour. 1976 Jan;35(224):32–38. [PubMed]
  • Thomson RH. The pigments of reddish hair and feathers. Angew Chem Int Ed Engl. 1974 May;13(5):305–312. [PubMed]
  • Dryja TP, O'Neil-Dryja M, Albert DM. Elemental analysis of melanins from bovine hair, iris, choroid, and retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1979 Mar;18(3):231–236. [PubMed]
  • Ito S, Novellino E, Chioccara F, Misuraca G, Prota G. Co-polymerization of dopa and cysteinyldopa in melanogenesis in vitro. Experientia. 1980 Jul 15;36(7):822–823. [PubMed]
  • Menon IA, Persad S, Haberman HF, Kurian CJ. A comparative study of the physical and chemical properties of melanins isolated from human black and red hair. J Invest Dermatol. 1983 Mar;80(3):202–206. [PubMed]
  • Ito S, Jimbow K. Quantitative analysis of eumelanin and pheomelanin in hair and melanomas. J Invest Dermatol. 1983 Apr;80(4):268–272. [PubMed]
  • Menon IA, Persad S, Haberman HF, Kurian CJ, Basu PK. A qualitative study of the melanins from blue and brown human eyes. Exp Eye Res. 1982 Apr;34(4):531–537. [PubMed]
  • Sealy RC, Hyde JS, Felix CC, Menon IA, Prota G. Eumelanins and pheomelanins: characterization by electron spin resonance spectroscopy. Science. 1982 Aug 6;217(4559):545–547. [PubMed]
  • Jimbow K, Ishida O, Ito S, Hori Y, Witkop CJ, Jr, King RA. Combined chemical and electron microscopic studies of pheomelanosomes in human red hair. J Invest Dermatol. 1983 Dec;81(6):506–511. [PubMed]
  • Jimbow K, Miyake Y, Homma K, Yasuda K, Izumi Y, Tsutsumi A, Ito S. Characterization of melanogenesis and morphogenesis of melanosomes by physicochemical properties of melanin and melanosomes in malignant melanoma. Cancer Res. 1984 Mar;44(3):1128–1134. [PubMed]
  • Sealy RC, Hyde JS, Felix CC, Menon IA, Prota G, Swartz HM, Persad S, Haberman HF. Novel free radicals in synthetic and natural pheomelanins: distinction between dopa melanins and cysteinyldopa melanins by ESR spectroscopy. Proc Natl Acad Sci U S A. 1982 May;79(9):2885–2889. [PubMed]
  • Menon IA, Persad S, Ranadive NS, Haberman HF. Role of superoxide and hydrogen peroxide in cell lysis during irradiation in vitro of Ehrlich ascitic carcinoma cells in the presence of melanin. Can J Biochem Cell Biol. 1985 Apr;63(4):278–283. [PubMed]
  • Persad S, Menon IA, Haberman HF. Comparison of the effects of UV-visible irradiation of melanins and melanin-hematoporphyrin complexes from human black and red hair. Photochem Photobiol. 1983 Jan;37(1):63–68. [PubMed]
  • Menon IA, Persad S, Ranadive NS, Haberman HF. Effects of ultraviolet-visible irradiation in the presence of melanin isolated from human black or red hair upon Ehrlich ascites carcinoma cells. Cancer Res. 1983 Jul;43(7):3165–3169. [PubMed]
  • Wang RJ, Nixon BR. Identification of hydrogen peroxide as a photoproduct toxic to human cells in tissue-culture medium irradiated with "daylight" fluorescent light. In Vitro. 1978 Aug;14(8):715–722. [PubMed]

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