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Br J Ophthalmol. 1985 March; 69(3): 217–218.
PMCID: PMC1040566

Penetration of timolol eye drops into human aqueous humour: the first hour.


Samples of aqueous humour were removed from 26 eyes at the start of cataract extraction. Two drops of timolol 0.5% had been instilled into the conjunctival sac 12-71 minutes before operation. Analysis by gas chromatography showed a mean timolol concentration of 55.46 ng/mg, with a range of 8 to 100 ng/mg.

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Selected References

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  • Phillips CI, Bartholomew RS, Kazi G, Schmitt CJ, Vogel R. Penetration of timolol eye drops into human aqueous humour. Br J Ophthalmol. 1981 Sep;65(9):593–595. [PMC free article] [PubMed]
  • Ros FE, Innemee HC, van Zwieten PA. Penetration of atenolol in the rabbit eye. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Nov 30;208(4):235–240. [PubMed]
  • Ros FE, Innemee HC, van Zwieten PA. Ocular penetration of beta-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol. Doc Ophthalmol. 1980 Apr 15;48(2):291–301. [PubMed]
  • Schmitt CJ, Lotti VJ, LeDouarec JC. Penetration of timolol into the rabbit eye. Measurements after ocular instillation and intravenous injection. Arch Ophthalmol. 1980 Mar;98(3):547–551. [PubMed]
  • Schmitt C, Lotti VJ, Le Douarec JC. Penetration of five beta-adrenergic antagonists into the rabbit eye after ocular instillation. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;217(3):167–174. [PubMed]
  • Tocco DJ, deLuna FA, Duncan AE. Electron-capture GLC determination of timolol in human plasma and urine. J Pharm Sci. 1975 Nov;64(11):1879–1881. [PubMed]

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