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Br J Ophthalmol. 1984 August; 68(8): 561–569.
PMCID: PMC1040413

Prolonged rod dark adaptation in retinitis pigmentosa.


The time course of rod dark adaptation was measured in 12 patients and carriers of retinitis pigmentosa (RP). In contrast to previous studies the rod absolute threshold was determined prior to any exposure to the bleaching light. For seven of the patients and carriers the recovery of rod sensitivity to the prebleach level was prolonged, with the delay ranging from mild to severe. The prolongation appeared to be limited to the late phase of bleaching recovery; the early portion of rod dark adaptation, measured following a weak bleach, was normal. These results suggest a selective impairment in the processes underlying rod dark adaptation in some patients with RP.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Merin S, Auerbach E. Retinitis pigmentosa. Surv Ophthalmol. 1976 Mar-Apr;20(5):303–346. [PubMed]
  • WALD G, ZEAVIN BH. Rod and cone vision in retinitis pigmentosa. Am J Ophthalmol. 1956 Oct;42(4 Pt 2):253–269. [PubMed]
  • GOODMAN G, GUNKEL RD. Familial electroretinographic and adaptometric studies in retinitis pigmentosa. Am J Ophthalmol. 1958 Sep;46(3 Pt 2):142–178. [PubMed]
  • Pugh EN. Rushton's paradox: rod dark adaptation after flash photolysis. J Physiol. 1975 Jun;248(2):413–431. [PubMed]
  • RUSHTON WA. Rhodopsin measurement and dark-adaptation in a subject deficient in cone vision. J Physiol. 1961 Apr;156:193–205. [PubMed]
  • Alpern M. Rhodopsin kinetics in the human eye. J Physiol. 1971 Sep;217(2):447–471. [PubMed]
  • Rushton WA, Powell DS. The rhodopsin content and the visual threshold of human rods. Vision Res. 1972 Jun;12(6):1073–1081. [PubMed]
  • Lamb TD. The involvement of rod photoreceptors in dark adaptation. Vision Res. 1981;21(12):1773–1782. [PubMed]
  • Fishman GA, Anderson RJ, Stinson L, Haque A. Driving performance of retinitis pigmentosa patients. Br J Ophthalmol. 1981 Feb;65(2):122–126. [PMC free article] [PubMed]
  • Massof RW, Finkelstein D. Two forms of autosomal dominant primary retinitis pigmentosa. Doc Ophthalmol. 1981 Nov;51(4):289–346. [PubMed]
  • Hecht S, Haig C, Wald G. THE DARK ADAPTATION OF RETINAL FIELDS OF DIFFERENT SIZE AND LOCATION. J Gen Physiol. 1935 Nov 20;19(2):321–337. [PMC free article] [PubMed]
  • Alpern M, Krantz DH. Visual pigment kinetics in abnormalities of the uvea-retinal epithelium interface in man. Invest Ophthalmol Vis Sci. 1981 Feb;20(2):183–203. [PubMed]
  • Dowling JE, Ripps H. Adaptation in skate photoreceptors. J Gen Physiol. 1972 Dec;60(6):698–719. [PMC free article] [PubMed]
  • Rushton WA, Powell DS. The early phase of dark adaptation. Vision Res. 1972 Jun;12(6):1083–1093. [PubMed]
  • Highman VN, Weale RA. Rhodopsin density and visual threshold in retinitis pigmentosa. Am J Ophthalmol. 1973 May;75(5):822–832. [PubMed]
  • Ripps H, Brin KP, Weale RA. Rhodopsin and visual threshold in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1978 Aug;17(8):735–745. [PubMed]

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