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Br J Ind Med. 1992 November; 49(11): 791–798.
PMCID: PMC1039327

A case-control study of motor neurone disease: its relation to heritability, and occupational exposures, particularly to solvents.


Motor neurone disease (MND) was studied in relation to various determinants in a case-control study covering nine counties in southern Sweden. A questionnaire about occupational exposures, medical history, lifestyle factors etc was given to all cases in the age range 45-79 and to a random sample of 500 population controls in the same age range. The questionnaires were answered by 92 cases and 372 controls, a response rate of 85% and 75% respectively. Among men high Mantel-Haenszel odds ratios (MHORs) were obtained for electricity work (MHOR = 6.7, 95% confidence interval (95% CI) 1.0-32.1), welding (MHOR = 3.7, 95% CI 1.1-13.0), and impregnating agents (MHOR = 3.5, 95% CI 0.9-13.1). Heritability with regard to a neurodegenerative disease or thyroid disease seemed to predispose to a risk of developing MND (OR = 2.1, 95% CI 1.0-4.3). The highest OR was found for the combination of such heritability, exposure to solvents, and male sex (OR = 15.6, 95% CI 2.8-87.0), a combination that occurred for seven cases and three controls. Hereditary factors and external exposures had a different distribution among cases with the spinal type of MND than among cases with involvement of the pyramidal tract or bulbar paresis also.

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Selected References

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  • Li TM, Alberman E, Swash M. Clinical features and associations of 560 cases of motor neuron disease. J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1043–1045. [PMC free article] [PubMed]
  • Rosen AD. Amyotrophic lateral sclerosis. Clinical features and prognosis. Arch Neurol. 1978 Oct;35(10):638–642. [PubMed]
  • Spencer PS. Guam ALS/parkinsonism-dementia: a long-latency neurotoxic disorder caused by "slow toxin(s)" in food? Can J Neurol Sci. 1987 Aug;14(3 Suppl):347–357. [PubMed]
  • Garruto RM, Yanagihara R, Gajdusek DC. Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam. Neurology. 1985 Feb;35(2):193–198. [PubMed]
  • Breland AE, Jr, Currier RD. Multiple sclerosis and amyotrophic lateral sclerosis in Mississippi. Neurology. 1967 Oct;17(10):1011–1016. [PubMed]
  • Campbell AM, Williams ER, Barltrop D. Motor neurone disease and exposure to lead. J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):877–885. [PMC free article] [PubMed]
  • Gawel M, Zaiwalla Z, Rose FC. Antecedent events in motor neuron disease. J Neurol Neurosurg Psychiatry. 1983 Nov;46(11):1041–1043. [PMC free article] [PubMed]
  • Murros K, Fogelholm R. Amyotrophic lateral sclerosis in Middle-Finland: an epidemiological study. Acta Neurol Scand. 1983 Jan;67(1):41–47. [PubMed]
  • Gallagher JP, Sanders M. Trauma and amyotrophic lateral sclerosis: a report of 78 patients. Acta Neurol Scand. 1987 Feb;75(2):145–150. [PubMed]
  • den Hartog Jager WA, Hanlo PW, Ansink BJ, Vermeulen MB. Results of a questionnaire in 100 ALS patients and 100 control cases. Clin Neurol Neurosurg. 1987;89(1):37–41. [PubMed]
  • Provinciali L, Giovagnoli AR. Antecedent events in amyotrophic lateral sclerosis: do they influence clinical onset and progression? Neuroepidemiology. 1990;9(5):255–262. [PubMed]
  • Chió A, Meineri P, Tribolo A, Schiffer D. Risk factors in motor neuron disease: a case-control study. Neuroepidemiology. 1991;10(4):174–184. [PubMed]
  • Hanisch R, Dworsky RL, Henderson BE. Letter: A search for clues to the cause of amyotrophic lateral sclerosis. Arch Neurol. 1976 Jun;33(6):456–457. [PubMed]
  • Pierce-Ruhland R, Patten BM. Repeat study of antecedent events in motor neuron disease. Ann Clin Res. 1981 Apr;13(2):102–107. [PubMed]
  • Roelofs-Iverson RA, Mulder DW, Elveback LR, Kurland LT, Molgaard CA. ALS and heavy metals: a pilot case-control study. Neurology. 1984 Mar;34(3):393–395. [PubMed]
  • Tarras S, Schenkman N, Boesch R, Mulvihill M, Caroscio JT. ALS and pet exposure. Neurology. 1985 May;35(5):717–720. [PubMed]
  • Deapen DM, Henderson BE. A case-control study of amyotrophic lateral sclerosis. Am J Epidemiol. 1986 May;123(5):790–799. [PubMed]
  • Gresham LS, Molgaard CA, Golbeck AL, Smith R. Amyotrophic lateral sclerosis and occupational heavy metal exposure: a case-control study. Neuroepidemiology. 1986;5(1):29–38. [PubMed]
  • Sienko DG, Davis JP, Taylor JA, Brooks BR. Amyotrophic lateral sclerosis. A case-control study following detection of a cluster in a small Wisconsin community. Arch Neurol. 1990 Jan;47(1):38–41. [PubMed]
  • Felmus MT, Patten BM, Swanke L. Antecedent events in amyotrophic lateral sclerosis. Neurology. 1976 Feb;26(2):167–172. [PubMed]
  • Kondo K, Tsubaki T. Case-control studies of motor neuron disease: association with mechanical injuries. Arch Neurol. 1981 Apr;38(4):220–226. [PubMed]
  • Armon C, Kurland LT, Daube JR, O'Brien PC. Epidemiologic correlates of sporadic amyotrophic lateral sclerosis. Neurology. 1991 Jul;41(7):1077–1084. [PubMed]
  • Kurtzke JF, Beebe GW. Epidemiology of amyotrophic lateral sclerosis: 1. A case-control comparison based on ALS deaths. Neurology. 1980 May;30(5):453–462. [PubMed]
  • Gunnarsson LG, Lindberg G, Söderfeldt B, Axelson O. Amyotrophic lateral sclerosis in Sweden in relation to occupation. Acta Neurol Scand. 1991 Jun;83(6):394–398. [PubMed]
  • Gunnarsson LG, Lindberg G, Söderfelt B, Axelson O. The mortality of motor neuron disease in Sweden. Arch Neurol. 1990 Jan;47(1):42–46. [PubMed]
  • Winokur A, Manaker S, Kreider MS. TRH and TRH receptors in the spinal cord. Ann N Y Acad Sci. 1989;553:314–324. [PubMed]

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