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J Neurol Neurosurg Psychiatry. 1988 April; 51(4): 540–543.
PMCID: PMC1032970

The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease.

Abstract

Significant loss of neurons in the pedunculopontine nucleus pars compacta (PPNc), a putative cholinergic nucleus involved in modulating somatic motor activities, has been demonstrated in progressive supranuclear palsy (PSP) and Parkinson's disease but not in Alzheimer's disease. A morphometric study of this nucleus was performed in two cases of PSP and in a cohort of cases of Parkinson's disease, Alzheimer's disease, senile dementia of Alzheimer type (SDAT), and age-matched controls. In PSP a significant 60% neuronal loss in PPNc was associated with neurofibrillary tangles in 40 to 64% of the remaining neurons. In Parkinson's disease there was a significant decrease in cell numbers and density by 53 and 51%, respectively, with Lewy bodies involving 6 to 39% of all neurons. In Alzheimer's disease and SDAT, large neurons were reduced by 29 and 33.8%, respectively, with tangles in 9 to 38% of the remaining cells. The selective affection of this putative cholinergic nucleus in PSP and Parkinson's disease appears to be related to motor dysfunctions in these disorders.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Sugimoto T, Hattori T. Organization and efferent projections of nucleus tegmenti pedunculopontinus pars compacta with special reference to its cholinergic aspects. Neuroscience. 1984 Apr;11(4):931–946. [PubMed]
  • Usunoff KG. Tegmentonigral projection in the cat: electron microscopic observations. Adv Neurol. 1984;40:55–61. [PubMed]
  • Beninato M, Spencer RF. A cholinergic projection to the rat substantia nigra from the pedunculopontine tegmental nucleus. Brain Res. 1987 May 26;412(1):169–174. [PubMed]
  • Mesulam MM, Mufson EJ, Levey AI, Wainer BH. Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Neuroscience. 1984 Jul;12(3):669–686. [PubMed]
  • Zweig RM, Whitehouse PJ, Casanova MF, Walker LC, Jankel WR, Price DL. Loss of pedunculopontine neurons in progressive supranuclear palsy. Ann Neurol. 1987 Jul;22(1):18–25. [PubMed]
  • Hirsch EC, Graybiel AM, Duyckaerts C, Javoy-Agid F. Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5976–5980. [PubMed]
  • Jellinger K, Riederer P, Tomonaga M. Progressive supranuclear palsy: clinico-pathological and biochemical studies. J Neural Transm Suppl. 1980;(16):111–128. [PubMed]
  • Jellinger K. Neuropathological substrates of Alzheimer's disease and Parkinson's disease. J Neural Transm Suppl. 1987;24:109–129. [PubMed]
  • Mann DM, Yates PO. Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders. Hum Neurobiol. 1986;5(3):147–158. [PubMed]
  • Chui HC, Mortimer JA, Slager U, Zarow C, Bondareff W, Webster DD. Pathologic correlates of dementia in Parkinson's disease. Arch Neurol. 1986 Oct;43(10):991–995. [PubMed]
  • Yamamoto T, Hirano A. Nucleus raphe dorsalis in Alzheimer's disease: neurofibrillary tangles and loss of large neurons. Ann Neurol. 1985 Jun;17(6):573–577. [PubMed]
  • Marcyniuk B, Mann DM, Yates PO. Loss of nerve cells from locus coeruleus in Alzheimer's disease is topographically arranged. Neurosci Lett. 1986 Mar 14;64(3):247–252. [PubMed]
  • Whitehouse PJ. The concept of subcortical and cortical dementia: another look. Ann Neurol. 1986 Jan;19(1):1–6. [PubMed]

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