PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
J Neurol Neurosurg Psychiatry. 1989 June; 52(6): 724–731.
PMCID: PMC1032022

Major depression in Parkinson's disease and the mood response to intravenous methylphenidate: possible role of the "hedonic" dopamine synapse.

Abstract

The euphoric response to equivalent doses of intravenous methylphenidate (MTP) was assessed in a group of 13 Parkinsonian patients affected by major depression, in a group of 11 nondepressed Parkinsonians, in a group of 14 nonparkinsonian subjects suffering from major depression, and finally in a group of 12 controls with no CNS or psychiatric disease. Subjects of all four groups were matched for age, sex and other main characteristics. Depressed and nondepressed Parkinsonians were also matched for duration and severity of illness, and for the type of antiparkinsonian treatment. The response to MTP was evaluated in the context of a double-blind, placebo-controlled study. Parkinsonian patients with major depression exhibited a significant lack of sensitivity to the euphoriant effects of MTP, in comparison with the other three groups. Euphoria produced by central stimulants has been shown to depend on the activity of a dopamine synapse in humans, which is thought to be situated at the limbic terminals of dopamine neurons located in the ventral tegmental area. Degeneration of this system may have predisposed our Parkinsonian patients to major depression.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.3M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Gotham AM, Brown RG, Marsden CD. Depression in Parkinson's disease: a quantitative and qualitative analysis. J Neurol Neurosurg Psychiatry. 1986 Apr;49(4):381–389. [PMC free article] [PubMed]
  • Warburton JW. Depressive symptoms in Parkinson patients referred for thalamotomy. J Neurol Neurosurg Psychiatry. 1967 Aug;30(4):368–370. [PMC free article] [PubMed]
  • Marsh GG, Markham CH. Does levodopa alter depression and psychopathology in Parkinsonism patients? J Neurol Neurosurg Psychiatry. 1973 Dec;36(6):925–935. [PMC free article] [PubMed]
  • Robins AH. Depression in patients with Parkinsonism. Br J Psychiatry. 1976 Feb;128:141–145. [PubMed]
  • Cantello R, Gilli M, Riccio A, Bergamasco B. Mood changes associated with "end-of-dose deterioration" in Parkinson's disease: a controlled study. J Neurol Neurosurg Psychiatry. 1986 Oct;49(10):1182–1190. [PMC free article] [PubMed]
  • Horn S. Some psychological factors in Parkinsonism. J Neurol Neurosurg Psychiatry. 1974 Jan;37(1):27–31. [PMC free article] [PubMed]
  • Celesia GG, Wanamaker WM. Psychiatric disturbances in Parkinson's disease. Dis Nerv Syst. 1972 Sep;33(9):577–583. [PubMed]
  • Mayeux R, Stern Y, Rosen J, Leventhal J. Depression, intellectual impairment, and Parkinson disease. Neurology. 1981 Jun;31(6):645–650. [PubMed]
  • Santamaría J, Tolosa E, Valles A. Parkinson's disease with depression: a possible subgroup of idiopathic parkinsonism. Neurology. 1986 Aug;36(8):1130–1133. [PubMed]
  • Taylor AE, Saint-Cyr JA, Lang AE, Kenny FT. Parkinson's disease and depression. A critical re-evaluation. Brain. 1986 Apr;109(Pt 2):279–292. [PubMed]
  • Mayeux R, Stern Y, Cote L, Williams JB. Altered serotonin metabolism in depressed patients with parkinson's disease. Neurology. 1984 May;34(5):642–646. [PubMed]
  • Kostić VS, Djuricić BM, Covicković-Sternić N, Bumbasirević L, Nikolić M, Mrsulja BB. Depression and Parkinson's disease: possible role of serotonergic mechanisms. J Neurol. 1987 Feb;234(2):94–96. [PubMed]
  • Fibiger HC. The neurobiological substrates of depression in Parkinson's disease: a hypothesis. Can J Neurol Sci. 1984 Feb;11(1 Suppl):105–107. [PubMed]
  • Van Kammen DP, Murphy DL. Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment. Psychopharmacologia. 1975 Nov 21;44(3):215–224. [PubMed]
  • Wald D, Ebstein RP, Belmaker RH. Haloperidol and lithium blocking of the mood response to intravenous methylphenidate. Psychopharmacology (Berl) 1978 Apr 14;57(1):83–87. [PubMed]
  • Brown P, Brawley P. Dexamethasone suppression test and mood response to methylphenidate in primary depression. Am J Psychiatry. 1983 Aug;140(8):990–993. [PubMed]
  • Martin WR, Sloan JW, Sapira JD, Jasinski DR. Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin Pharmacol Ther. 1971 Mar-Apr;12(2):245–258. [PubMed]
  • Hachinski VC, Iliff LD, Zilhka E, Du Boulay GH, McAllister VL, Marshall J, Russell RW, Symon L. Cerebral blood flow in dementia. Arch Neurol. 1975 Sep;32(9):632–637. [PubMed]
  • Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. [PubMed]
  • Ashall F, Bramwell ME, Harris H. A new marker for human cancer cells. 1 The Ca antigen and the Ca1 antibody. Lancet. 1982 Jul 3;2(8288):1–6. [PubMed]
  • Stern Y, Mayeux R, Rosen J. Contribution of perceptual motor dysfunction to construction and tracing disturbances in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1984 Sep;47(9):983–989. [PMC free article] [PubMed]
  • Direnfeld LK, Albert ML, Volicer L, Langlais PJ, Marquis J, Kaplan E. Parkinson's disease. The possible relationship of laterality to dementia and neurochemical findings. Arch Neurol. 1984 Sep;41(9):935–941. [PubMed]
  • Cantello R, Riccio A, Scarzella L, Leotta D, Bergamasco B. Depression in Parkinson disease: a disabling but neglected factor. Ital J Neurol Sci. 1984 Dec;5(4):417–422. [PubMed]
  • Fawcett J, Clark DC, Scheftner WA, Gibbons RD. Assessing anhedonia in psychiatric patients. Arch Gen Psychiatry. 1983 Jan;40(1):79–84. [PubMed]
  • HALLIDAY AM, NATHAN PW. Methyl phenidate in parkinsonism. Br Med J. 1961 Jun 10;1(5240):1652–1655. [PMC free article] [PubMed]
  • Cantello R, Aguggia M, Gilli M, Delsedime M, Riccio A, Rainero I, Mutani R. Analgesic action of methylphenidate on parkinsonian sensory symptoms. Mechanisms and pathophysiological implications. Arch Neurol. 1988 Sep;45(9):973–976. [PubMed]
  • Marsden CD, Parkes JD. "On-off" effects in patients with Parkinson's disease on chronic levodopa therapy. Lancet. 1976 Feb 7;1(7954):292–296. [PubMed]
  • Jönsson LE, Anggård E, Gunne LM. Blockade of intravenous amphetamine euphoria in man. Clin Pharmacol Ther. 1971 Nov-Dec;12(6):889–896. [PubMed]
  • Phelps ME, Mazziotta JC, Baxter L, Gerner R. Positron emission tomographic study of affective disorders: problems and strategies. Ann Neurol. 1984;15 (Suppl):S149–S156. [PubMed]
  • Phillips AG, Fibiger HC. The role of dopamine in maintaining intracranial self-stimulation in the ventral tegmentum, nucleus accumbens, and medial prefrontal cortex. Can J Psychol. 1978 Jun;32(2):58–66. [PubMed]
  • Lyness WH, Friedle NM, Moore KE. Destruction of dopaminergic nerve terminals in nucleus accumbens: effect on d-amphetamine self-administration. Pharmacol Biochem Behav. 1979 Nov;11(5):553–556. [PubMed]
  • Uhl GR, Hedreen JC, Price DL. Parkinson's disease: loss of neurons from the ventral tegmental area contralateral to therapeutic surgical lesions. Neurology. 1985 Aug;35(8):1215–1218. [PubMed]
  • Javoy-Agid F, Agid Y. Is the mesocortical dopaminergic system involved in Parkinson disease? Neurology. 1980 Dec;30(12):1326–1330. [PubMed]
  • Klein DF. Endogenomorphic depression. A conceptual and terminological revision. Arch Gen Psychiatry. 1974 Oct;31(4):447–454. [PubMed]
  • Meehl PE. Hedonic capacity: some conjectures. Bull Menninger Clin. 1975 Jul;39(4):295–307. [PubMed]
  • Nauta WJ, Domesick VB. Afferent and efferent relationships of the basal ganglia. Ciba Found Symp. 1984;107:3–29. [PubMed]
  • Gotham AM, Brown RG, Marsden CD. 'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa. Brain. 1988 Apr;111(Pt 2):299–321. [PubMed]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Group