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J Neurol Neurosurg Psychiatry. 1989 August; 52(8): 980–985.
PMCID: PMC1031838

EEG spectral analysis in delirium.


Spectral analysis of EEG was conducted for 51 elderly delirious patients meeting the Diagnostic and Statistical Manual of Mental Disorders III (DSM-III) criteria and for 19 controls. As a whole group, and also when subdivided according to the type of delirium, severity of cognitive decline or the type of central nervous system disease, delirious patients showed significant reductions of alpha percentage, increased theta and delta activity and slowing of the peak and mean frequencies and these changes were also obvious in individual recordings. The alpha percentage and various ratio parameters correlated significantly with Mini Mental State score, and delta percentage and mean frequency with the lengths of delirium and hospitalisation. The results indicate an association between spectral EEG changes and severity of cognitive deterioration in delirium.

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Selected References

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  • ENGEL GL, ROMANO J. Delirium, a syndrome of cerebral insufficiency. J Chronic Dis. 1959 Mar;9(3):260–277. [PubMed]
  • Lipowski ZJ. Organic brain syndromes: a reformulation. Compr Psychiatry. 1978 Jul-Aug;19(4):309–322. [PubMed]
  • Lipowski ZJ. Delirium (acute confusional states). JAMA. 1987 Oct 2;258(13):1789–1792. [PubMed]
  • Rabins PV, Folstein MF. Delirium and dementia: diagnostic criteria and fatality rates. Br J Psychiatry. 1982 Feb;140:149–153. [PubMed]
  • Lipowski ZJ. Transient cognitive disorders (delirium, acute confusional states) in the elderly. Am J Psychiatry. 1983 Nov;140(11):1426–1436. [PubMed]
  • Gordon EB, Sim M. The E.E.G. in presenile dementia. J Neurol Neurosurg Psychiatry. 1967 Jun;30(3):285–291. [PMC free article] [PubMed]
  • Johannesson G, Hagberg B, Gustafson L, Ingvar DH. EEG and cognitive impairment in presenile dementia. Acta Neurol Scand. 1979 May;59(5):225–240. [PubMed]
  • Kaszniak AW, Garron DC, Fox JH, Bergen D, Huckman M. Cerebral atrophy, EEG slowing age, education, and cognitive functioning in suspected dementia. Neurology. 1979 Sep;29(9 Pt 1):1273–1279. [PubMed]
  • Duffy FH, Albert MS, McAnulty G. Brain electrical activity in patients with presenile and senile dementia of the Alzheimer type. Ann Neurol. 1984 Oct;16(4):439–448. [PubMed]
  • Giaquinto S, Nolfe G. The EEG in the normal elderly: a contribution to the interpretation of aging and dementia. Electroencephalogr Clin Neurophysiol. 1986 Jun;63(6):540–546. [PubMed]
  • Erkinjuntti T, Larsen T, Sulkava R, Ketonen L, Laaksonen R, Palo J. EEG in the differential diagnosis between Alzheimer's disease and vascular dementia. Acta Neurol Scand. 1988 Jan;77(1):36–43. [PubMed]
  • Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. [PubMed]
  • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 Jul;34(7):939–944. [PubMed]
  • Penttilä M, Partanen JV, Soininen H, Riekkinen PJ. Quantitative analysis of occipital EEG in different stages of Alzheimer's disease. Electroencephalogr Clin Neurophysiol. 1985 Jan;60(1):1–6. [PubMed]
  • Soininen H, Partanen VJ, Helkala EL, Riekkinen PJ. EEG findings in senile dementia and normal aging. Acta Neurol Scand. 1982 Jan;65(1):59–70. [PubMed]
  • Soininen H, Partanen J, Laulumaa V, Helkala EL, Laakso M, Riekkinen PJ. Longitudinal EEG spectral analysis in early stage of Alzheimer's disease. Electroencephalogr Clin Neurophysiol. 1989 Apr;72(4):290–297. [PubMed]
  • Pro JD, Wells CE. The use of the electroencephalogram in the diagnosis of delirium. Dis Nerv Syst. 1977 Oct;38(10):804–808. [PubMed]
  • Obrecht R, Okhomina FO, Scott DF. Value of EEG in acute confusional states. J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):75–77. [PMC free article] [PubMed]
  • Nuwer MR. Quantitative EEG: I. Techniques and problems of frequency analysis and topographic mapping. J Clin Neurophysiol. 1988 Jan;5(1):1–43. [PubMed]
  • OBRIST WD. The electroencephalogram of normal aged adults. Electroencephalogr Clin Neurophysiol. 1954 May;6(2):235–244. [PubMed]
  • Busse EW, Wang HS. The value of electroencephalography in geriatrics. Geriatrics. 1965 Nov;20(11):906–924. [PubMed]
  • Itil T, Fink M. Anticholinergic drug-induced delirium: experimental modification, quantitative EEG and behavioral correlations. J Nerv Ment Dis. 1966 Dec;143(6):492–507. [PubMed]
  • Andriola MR. Role of the EEG in evaluating central nervous system dysfunction. Geriatrics. 1978 Feb;33(2):59–65. [PubMed]
  • Schaul N, Green L, Peyster R, Gotman J. Structural determinants of electroencephalographic findings in acute hemispheric lesions. Ann Neurol. 1986 Dec;20(6):703–711. [PubMed]
  • van Sweden B. Neuroleptic neurotoxicity; electro-clinical aspects. Acta Neurol Scand. 1984 Mar;69(3):137–146. [PubMed]
  • Nuwer MR. Quantitative EEG: II. Frequency analysis and topographic mapping in clinical settings. J Clin Neurophysiol. 1988 Jan;5(1):45–85. [PubMed]
  • Coben LA, Danziger W, Storandt M. A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and at 2.5 years. Electroencephalogr Clin Neurophysiol. 1985 Aug;61(2):101–112. [PubMed]
  • Gloor P, Ball G, Schaul N. Brain lesions that produce delta waves in the EEG. Neurology. 1977 Apr;27(4):326–333. [PubMed]
  • Müller HF, Schwartz G. Electroencephalograms and autopsy findings in geropsychiatry. J Gerontol. 1978 Jul;33(4):504–513. [PubMed]
  • Stewart DJ, MacFabe DF, Vanderwolf CH. Cholinergic activation of the electrocorticogram: role of the substantia innominata and effects of atropine and quinuclidinyl benzilate. Brain Res. 1984 Nov 26;322(2):219–232. [PubMed]
  • Klass DW, Westmoreland BF. Nonepileptogenic epileptiform electroencephalographic activity. Ann Neurol. 1985 Dec;18(6):627–635. [PubMed]
  • Vanderwolf CH, Gutman M, Baker GB. Hypothalamic self-stimulation: the role of dopamine and possible relations to neocortical slow wave activity. Behav Brain Res. 1984 Apr;12(1):9–19. [PubMed]
  • Millaud F. Electroencéphalographie et syndrome confusionnel dans un centre hospitalier spécialisé en psychiatrie. Encephale. 1986 Sep-Oct;12(5):273–277. [PubMed]

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