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Arch Dis Child. 1994 September; 71(3): 235–238.
PMCID: PMC1029978

Osteopenia in cerebral palsy.

Abstract

The bone mineral density of the lumbar spine was assessed in nine non-ambulant children with cerebral palsy combined with measurements of serum 25-hydroxyvitamin D, parathyroid hormone, and urinary calcium excretion. Three children with recurrent fractures received treatment with bisphosphonates for periods ranging from 12-18 months. All the children demonstrated a severe reduction in bone mineral density even when allowance was made for their body weight. There were no consistent abnormalities of vitamin D or parathyroid hormone status. Three children had gross hypercalciuria. Each of the children treated with bisphosphonates demonstrated an increment in bone density ranging from 20-40% with no apparent adverse effects.

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Selected References

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  • Davie MW, Haddaway MJ. Bone mineral content and density in healthy subjects and in osteogenesis imperfecta. Arch Dis Child. 1994 Apr;70(4):331–334. [PMC free article] [PubMed]
  • Carter DR, Bouxsein ML, Marcus R. New approaches for interpreting projected bone densitometry data. J Bone Miner Res. 1992 Feb;7(2):137–145. [PubMed]
  • Shaw NJ, Wheeldon J, Brocklebank JT. Indices of intact serum parathyroid hormone and renal excretion of calcium, phosphate, and magnesium. Arch Dis Child. 1990 Nov;65(11):1208–1211. [PMC free article] [PubMed]
  • Rosenstein BD, Greene WB, Herrington RT, Blum AS. Bone density in myelomeningocele: the effects of ambulatory status and other factors. Dev Med Child Neurol. 1987 Aug;29(4):486–494. [PubMed]
  • Mazess RB, Whedon GD. Immobilization and bone. Calcif Tissue Int. 1983 May;35(3):265–267. [PubMed]
  • Slemenda CW, Miller JZ, Hui SL, Reister TK, Johnston CC., Jr Role of physical activity in the development of skeletal mass in children. J Bone Miner Res. 1991 Nov;6(11):1227–1233. [PubMed]
  • Dent CE, Richens A, Rowe DJ, Stamp TC. Osteomalacia with long-term anticonvulsant therapy in epilepsy. Br Med J. 1970 Oct 10;4(5727):69–72. [PMC free article] [PubMed]
  • Hahn TJ. Drug-induced disorders of vitamin D and mineral metabolism. Clin Endocrinol Metab. 1980 Mar;9(1):107–127. [PubMed]
  • Kruse K. On the pathogenesis of anticonvulsant-drug-induced alterations of calcium metabolism. Eur J Pediatr. 1982 May;138(3):202–205. [PubMed]
  • Storm T, Thamsborg G, Steiniche T, Genant HK, Sørensen OH. Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. N Engl J Med. 1990 May 3;322(18):1265–1271. [PubMed]
  • McCloskey EV, Yates AJ, Gray RE, Hamdy NA, Galloway J, Kanis JA. Diphosphonates and phosphate homoeostasis in man. Clin Sci (Lond) 1988 Jun;74(6):607–612. [PubMed]
  • Nagant de Deuxchaisnes C, Rombouts-Lindemans C, Huaux JP, Devogelaer JP. Diphosphonates and inhibition of bone mineralization. Lancet. 1982 Sep 11;2(8298):607–608. [PubMed]

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