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Arch Dis Child. 1993 June; 68(6): 724–728.
PMCID: PMC1029361

Infant feeding, wheezing, and allergy: a prospective study.


The determinants of wheezing and allergy were investigated in 453 children with a family history of allergic disease. A randomised controlled trial examined the effects of withholding cows' milk protein during the first three months of life and replacing cows' milk with soya milk. The children were followed up to the age of 7 years. Withholding cows' milk did not reduce the incidence of allergy or wheezing. Children who had ever been breast fed had a lower incidence of wheeze than those who had not (59% and 74% respectively). The effect persisted to age 7 years in the non-atopics only, the risk of wheeze being halved in the breast fed children after allowing for employment status, sex passive smoking, and overcrowding. Allergic disease was not associated with exposure to tobacco smoke, house dust mite antigen, or cats. Breast feeding may confer long term protection against respiratory infection.

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  • Miskelly FG, Burr ML, Vaughan-Williams E, Fehily AM, Butland BK, Merrett TG. Infant feeding and allergy. Arch Dis Child. 1988 Apr;63(4):388–393. [PMC free article] [PubMed]
  • Burr ML, Miskelly FG, Butland BK, Merrett TG, Vaughan-Williams E. Environmental factors and symptoms in infants at high risk of allergy. J Epidemiol Community Health. 1989 Jun;43(2):125–132. [PMC free article] [PubMed]
  • Colley JR, Reid DD. Urban and social origins of childhood bronchitis in England and Wales. Br Med J. 1970 Apr 25;2(5703):213–217. [PMC free article] [PubMed]
  • Johnstone DE, Dutton AM. Dietary prophylaxis of allergic disease in children. N Engl J Med. 1966 Mar 31;274(13):715–719. [PubMed]
  • Merrett TG, Burr ML, Butland BK, Merrett J, Miskelly FG, Vaughan-Williams E. Infant feeding and allergy: 12-month prospective study of 500 babies born into allergic families. Ann Allergy. 1988 Dec;61(6 Pt 2):13–20. [PubMed]
  • Burr ML, St Leger AS, Bevan C, Merrett TG. A community survey of asthmatic characteristics. Thorax. 1975 Dec;30(6):663–668. [PMC free article] [PubMed]
  • Luczynska CM, Arruda LK, Platts-Mills TA, Miller JD, Lopez M, Chapman MD. A two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I. J Immunol Methods. 1989 Mar 31;118(2):227–235. [PubMed]
  • Sporik R, Holgate ST, Cogswell JJ. Natural history of asthma in childhood--a birth cohort study. Arch Dis Child. 1991 Sep;66(9):1050–1053. [PMC free article] [PubMed]
  • Arbeiter HI. How prevalent is allergy among United States school children? A survey of findings in the Munster (Indiana) school system. Clin Pediatr (Phila) 1967 Mar;6(3):140–142. [PubMed]
  • Kjellman NI. Atopic disease in seven-year-old children. Incidence in relation to family history. Acta Paediatr Scand. 1977 Jul;66(4):465–471. [PubMed]
  • Kjellman NI, Johansson SG. Soy versus cow's milk in infants with a biparental history of atopic disease: development of atopic disease and immunoglobulins from birth to 4 years of age. Clin Allergy. 1979 Jul;9(4):347–358. [PubMed]
  • Gruskay FL. Comparison of breast, cow, and soy feedings in the prevention of onset of allergic disease: a 15-year prospective study. Clin Pediatr (Phila) 1982 Aug;21(8):486–491. [PubMed]
  • Moore WJ, Midwinter RE, Morris AF, Colley JR, Soothill JF. Infant feeding and subsequent risk of atopic eczema. Arch Dis Child. 1985 Aug;60(8):722–726. [PMC free article] [PubMed]
  • Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990 Aug 23;323(8):502–507. [PubMed]
  • Suoniemi I, Björkstén F, Haahtela T. Dependence of immediate hypersensitivity in the adolescent period on factors encountered in infancy. Allergy. 1981 May;36(4):263–268. [PubMed]
  • Brunekreef B, Groot B, Hoek G. Pets, allergy and respiratory symptoms in children. Int J Epidemiol. 1992 Apr;21(2):338–342. [PubMed]
  • Warner JA. Environmental allergen exposure in homes and schools. Clin Exp Allergy. 1992 Dec;22(12):1044–1045. [PubMed]
  • Strachan DP. Causes and control of chronic respiratory disease: looking beyond the smokescreen. J Epidemiol Community Health. 1992 Jun;46(3):177–179. [PMC free article] [PubMed]
  • Chen Y, Li W, Yu S. Influence of passive smoking on admissions for respiratory illness in early childhood. Br Med J (Clin Res Ed) 1986 Aug 2;293(6542):303–306. [PMC free article] [PubMed]
  • Cogswell JJ, Mitchell EB, Alexander J. Parental smoking, breast feeding, and respiratory infection in development of allergic diseases. Arch Dis Child. 1987 Apr;62(4):338–344. [PMC free article] [PubMed]
  • Magnusson CG. Maternal smoking influences cord serum IgE and IgD levels and increases the risk for subsequent infant allergy. J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):898–904. [PubMed]
  • Fergusson DM, Horwood LJ, Beautrais AL, Shannon FT, Taylor B. Eczema and infant diet. Clin Allergy. 1981 Jul;11(4):325–331. [PubMed]
  • Kramer MS, Moroz B. Do breast-feeding and delayed introduction of solid foods protect against subsequent atopic eczema? J Pediatr. 1981 Apr;98(4):546–550. [PubMed]
  • Taylor B, Wadsworth J, Golding J, Butler N. Breast feeding, eczema, asthma, and hayfever. J Epidemiol Community Health. 1983 Jun;37(2):95–99. [PMC free article] [PubMed]
  • Chandra RK. Prospective studies of the effect of breast feeding on incidence of infection and allergy. Acta Paediatr Scand. 1979 Sep;68(5):691–694. [PubMed]
  • Pratt HF. Breastfeeding and eczema. Early Hum Dev. 1984 Apr;9(3):283–290. [PubMed]
  • Arshad SH, Matthews S, Gant C, Hide DW. Effect of allergen avoidance on development of allergic disorders in infancy. Lancet. 1992 Jun 20;339(8808):1493–1497. [PubMed]
  • Downham MA, Scott R, Sims DG, Webb JK, Gardner PS. Breast-feeding protects against respiratory syncytial virus infections. Br Med J. 1976 Jul 31;2(6030):274–276. [PMC free article] [PubMed]
  • Pullan CR, Toms GL, Martin AJ, Gardner PS, Webb JK, Appleton DR. Breast-feeding and respiratory syncytial virus infection. Br Med J. 1980 Oct 18;281(6247):1034–1036. [PMC free article] [PubMed]
  • Victora CG, Smith PG, Vaughan JP, Nobre LC, Lombardi C, Teixeira AM, Fuchs SM, Moreira LB, Gigante LP, Barros FC. Evidence for protection by breast-feeding against infant deaths from infectious diseases in Brazil. Lancet. 1987 Aug 8;2(8554):319–322. [PubMed]
  • Narayanan I, Prakash K, Prabhakar AK, Gujral VV. A planned prospective evaluation of the anti-infective property of varying quantities of expressed human milk. Acta Paediatr Scand. 1982 May;71(3):441–445. [PubMed]
  • Sims DG, Gardner PS, Weightman D, Turner MW, Soothill JF. Atopy does not predispose to RSV bronchiolitis or postbronchiolitic wheezing. Br Med J (Clin Res Ed) 1981 Jun 27;282(6282):2086–2088. [PMC free article] [PubMed]
  • Pullan CR, Hey EN. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br Med J (Clin Res Ed) 1982 Jun 5;284(6330):1665–1669. [PMC free article] [PubMed]

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