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J Neurol Neurosurg Psychiatry. 1986 September; 49(9): 991–996.
PMCID: PMC1029001

The syndrome of Karl Ludwig Kahlbaum.


Karl Ludwig Kahlbaum was the first to describe catatonia in 1868. There has been a tendency to consider catatonia as a psychiatric disease despite many case reports demonstrating a wide range of medical and neurological as well as psychiatric causes. We present our accumulated experience of the catatonic syndrome. Most cases (36%) were associated with affective illness but five cases (20%) had a defined organic disorder. A significant minority had no identifiable cause and there was only one case of schizophrenia. The idiopathic and affective groups had a high incidence of recurrent catatonic episodes and many had a family history of a similar problem. The prognosis was excellent, except for the few patients who presented with the acute and rapidly progressive form of the syndrome which led to acute renal failure.

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Selected References

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  • Gelenberg AJ. The catatonic syndrome. Lancet. 1976 Jun 19;1(7973):1339–1341. [PubMed]
  • Freeman JM, Finkelstein JD, Mudd SH. Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity. N Engl J Med. 1975 Mar 6;292(10):491–496. [PubMed]
  • Cooper AF, Schapira K. Case report: depression, catatonic stupor, and EEG changes in hyperparathyroidism. Psychol Med. 1973 Nov;3(4):509–515. [PubMed]
  • FREEMAN JG. Acute intermittent porphyria; associated psychiatric symptoms treated by electroshock. Proc Staff Meet Mayo Clin. 1951 Oct 24;26(22):401–406. [PubMed]
  • Offenstadt G, Bienvenu MP, Héricord P, Tawill S, Amstutz P. Catatonie grave, schizophrénie et coproporphyrie héréditaire. Sem Hop. 1980 Nov 8;56(41-42):1727–1730. [PubMed]
  • Steinman TI, Yager HM. Catatonia in uremia. Ann Intern Med. 1978 Jul;89(1):74–75. [PubMed]
  • Sher A, Andersen JM, Bhatia SC. Primidone-induced catatonic schizophrenia. Drug Intell Clin Pharm. 1983 Jul-Aug;17(7-8):551–552. [PubMed]
  • Weddington WW, Jr, Marks RC, Verghese JP. Disulfiram encephalopathy as a cause of the catatonia syndrome. Am J Psychiatry. 1980 Oct;137(10):1217–1219. [PubMed]
  • Good MI. Catatonialike symptomatology and withdrawal dyskinesias. Am J Psychiatry. 1976 Dec;133(12):1454–1456. [PubMed]
  • Engquist A, Jørgensen BC, Andersen HB. Catatonia after epidural morphine. Acta Anaesthesiol Scand. 1981 Oct;25(5):445–446. [PubMed]
  • MAY RH. Catatonic-like states following phenothiazine therapy. Am J Psychiatry. 1959 Jun;115(12):1119–1120. [PubMed]
  • Gelenberg AJ, Mandel MR. Catatonic reactions to high-potency neuroleptic drugs. Arch Gen Psychiatry. 1977 Aug;34(8):947–950. [PubMed]
  • Weinberger DR, Kelly MJ. Catatonia and malignant syndrome: a possible complication of neuroleptic administration. Report of a case involving haloperidol. J Nerv Ment Dis. 1977 Oct;165(4):263–268. [PubMed]
  • Warner AM, Pierozynski G. Pseudocatatonia associated with abuse of amphetamine and cannabis. Postgrad Med. 1977 Jan;61(1):275–277. [PubMed]
  • Janowsky DS, el-Yousel MK, Davis JM, Sekerke HJ. Provocation of schizophrenic symptoms by intravenous administration of methylphenidate. Arch Gen Psychiatry. 1973 Feb;28(2):185–191. [PubMed]
  • Sullivan BJ, Dickerman JD. Steroid-associated catatonia: report of a case. Pediatrics. 1979 Apr;63(4):677–679. [PubMed]
  • Hanson GD, Brown MJ. Waxy flexibility in a postpartum woman--a case report and review of the catatonic syndrome. Psychiatr Q. 1973;47(1):95–103. [PubMed]
  • Thompson GN. Cerebral lesions simulating schizophrenia: three case reports. Biol Psychiatry. 1970 Jan;2(1):59–64. [PubMed]
  • Solomon JG. Distinguishing catatonia: a case report. Psychosomatics. 1978 May;19(5):299–307. [PubMed]
  • Tippin J, Dunner FJ. Biparietal infarctions in a patient with Catatonia. Am J Psychiatry. 1981 Oct;138(10):1386–1387. [PubMed]
  • Gangadhar BN, Keshavan MS, Goswami U, Rao TV. Cortical venous thrombosis presenting as catatonia: a clinicopathologic report. J Clin Psychiatry. 1983 Mar;44(3):109–110. [PubMed]
  • Read SL. Catatonia in thrombotic thrombocytopenic purpura: case report. J Clin Psychiatry. 1983 Sep;44(9):343–344. [PubMed]
  • de Morsier G. Trois cas de tumeur du septum, développées dans le ventricule latéral, avec troubles du comportement. "Schizophrénie" et tumeur cérébrale. Encephale. 1968 Mar-Apr;57(2):181–193. [PubMed]
  • Malamud N. Psychiatric disorder with intracranial tumors of limbic system. Arch Neurol. 1967 Aug;17(2):113–123. [PubMed]
  • NEWMANN MA. Periventricular diffuse pinealoma: report of a case with clinical features of catatonic schizophrenia. J Nerv Ment Dis. 1955 Mar;121(3):193–204. [PubMed]
  • Schaumburg HH, Suzuki K. Non-specific familial presenile dementia. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):479–486. [PMC free article] [PubMed]
  • METTLER FA. Perceptual capacity, functions of the corpus striatum and schizophrenia. Psychiatr Q. 1955;29(1):89–111. [PubMed]
  • Thompson SW, Greenhouse AH. Petit mal status in adults. Ann Intern Med. 1968 Jun;68(6):1271–1279. [PubMed]
  • Kramer MS. Menstrual epileptoid psychosis in an adolescent girl. Am J Dis Child. 1977 Mar;131(3):316–317. [PubMed]
  • Shah P, Kaplan SL. Catatonic symptoms in a child with epilepsy. Am J Psychiatry. 1980 Jun;137(6):738–739. [PubMed]
  • Raskin DE, Frank SW. Herpes encephalitis with catatonic stupor. Arch Gen Psychiatry. 1974 Oct;31(4):544–546. [PubMed]
  • BRAGE D, PEDACE EA, NAPOLITANO AG. Estupor hipotalamico por hidatide diencefalohipofisaria: mutismo aquinetico de Cairns. Prensa Med Argent. 1956 Sep 28;43(39):2954–2959. [PubMed]
  • Durrant W. Catatonia after malaria. Br Med J. 1977 Oct 1;2(6091):893–893. [PMC free article] [PubMed]
  • Kim CH, Perlstein MA. Encephalitis with catatonic schizophrenic symptoms. IMJ Ill Med J. 1970 Nov;138(5):503–507. [PubMed]
  • Koehler K, Jakumeit U. Subacute sclerosing panencephalitis presenting as Leonhard's speech-prompt catatonia. Br J Psychiatry. 1976 Jul;129:29–31. [PubMed]
  • Breakey WR, Kala AK. Typhoid catatonia responsive to ECT. Br Med J. 1977 Aug 6;2(6083):357–359. [PMC free article] [PubMed]
  • Woods SW. Catatonia in a patient with subdural hematomas. Am J Psychiatry. 1980 Aug;137(8):983–984. [PubMed]
  • Ruff RL, Russakoff LM. Catatonia with frontal lobe atrophy. J Neurol Neurosurg Psychiatry. 1980 Feb;43(2):185–187. [PMC free article] [PubMed]
  • FOLTZ EL, WARD AA., Jr Communicating hydrocephalus from subarachnoid bleeding. J Neurosurg. 1956 Nov;13(6):546–566. [PubMed]
  • Matthews WB. Multiple sclerosis presenting with acute remitting psychiatric symptoms. J Neurol Neurosurg Psychiatry. 1979 Sep;42(9):859–863. [PMC free article] [PubMed]
  • Abrams R, Taylor MA. Catatonia. A prospective clinical study. Arch Gen Psychiatry. 1976 May;33(5):579–581. [PubMed]
  • Taylor MA, Abrams R. The phenomenology of mania. A new look at some old patients. Arch Gen Psychiatry. 1973 Oct;29(4):520–522. [PubMed]
  • Taylor MA, Abrams R. Catatonia. Prevalence and importance in the manic phase of manic-depressive illness. Arch Gen Psychiatry. 1977 Oct;34(10):1223–1225. [PubMed]
  • Waziri R. Catatonia. JAMA. 1977 Dec 5;238(23):2495–2496. [PubMed]
  • Henderson VW, Wooten GF. Neuroleptic malignant syndrome: a pathogenetic role for dopamine receptor blockade? Neurology. 1981 Feb;31(2):132–137. [PubMed]
  • Granato JE, Stern BJ, Ringel A, Karim AH, Krumholz A, Coyle J, Adler S. Neuroleptic malignant syndrome: successful treatment with dantrolene and bromocriptine. Ann Neurol. 1983 Jul;14(1):89–90. [PubMed]

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