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J Neurol Neurosurg Psychiatry. 1986 August; 49(8): 867–873.
PMCID: PMC1028946

Hypersexuality or altered sexual preference following brain injury.


Eight patients are described in whom either hypersexuality (four cases) or change in sexual preference (four cases) occurred following brain injury. In this series disinhibition of sexual activity and hypersexuality followed medial basal-frontal or diencephalic injury. This contrasted with the patients demonstrating altered sexual preference whose injuries involved limbic system structures. In some patients altered sexual behaviour may be the presenting or dominant feature of brain injury.

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Selected References

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  • Lisk RD. Increased sexual behavior in the male rat following lesions in the mammillary region. J Exp Zool. 1966 Feb;161(1):129–136. [PubMed]
  • Regestein QR, Reich P. Pedophilia occurring after onset of cognitive impairment. J Nerv Ment Dis. 1978 Nov;166(11):794–798. [PubMed]
  • Comings DE, Comings BG. A case of familial exhibitionism in Tourette's syndrome successfully treated with haloperidol. Am J Psychiatry. 1982 Jul;139(7):913–915. [PubMed]
  • Herzog AG, Russell V, Vaitukaitis JL, Geschwind N. Neuroendocrine dysfunction in temporal lobe epilepsy. Arch Neurol. 1982 Mar;39(3):133–135. [PubMed]
  • Rémillard GM, Andermann F, Testa GF, Gloor P, Aubé M, Martin JB, Feindel W, Guberman A, Simpson C. Sexual ictal manifestations predominate in women with temporal lobe epilepsy: a finding suggesting sexual dimorphism in the human brain. Neurology. 1983 Mar;33(3):323–330. [PubMed]
  • Blumer D. Hypersexual episodes in temporal lobe epilepsy. Am J Psychiatry. 1970 Feb;126(8):1099–1106. [PubMed]
  • Cummings JL, Mendez MF. Secondary mania with focal cerebrovascular lesions. Am J Psychiatry. 1984 Sep;141(9):1084–1087. [PubMed]
  • Berlin FS, Coyle GS. Sexual deviation syndromes. Johns Hopkins Med J. 1981 Sep;149(3):119–125. [PubMed]
  • Henn FA, Herjanic M, Vanderpearl RH. Forensic psychiatry: profiles of two types of sex offenders. Am J Psychiatry. 1976 Jun;133(6):694–696. [PubMed]
  • Lilly R, Cummings JL, Benson DF, Frankel M. The human Klüver-Bucy syndrome. Neurology. 1983 Sep;33(9):1141–1145. [PubMed]
  • TERZIAN H, ORE GD. Syndrome of Klüver and Bucy; reproduced in man by bilateral removal of the temporal lobes. Neurology. 1955 Jun;5(6):373–380. [PubMed]
  • Shraberg D, Weisberg L. The Klüver-Bucy syndrome in man. J Nerv Ment Dis. 1978 Feb;166(2):130–134. [PubMed]
  • Paulson GW. Use of pyridoxine in chorea. Am J Psychiatry. 1971 Feb;127(8):1091–1092. [PubMed]
  • Brown E, Brown GM, Kofman O, Quarrington B. Sexual function and affect in parkinsonian men treated with L-dopa. Am J Psychiatry. 1978 Dec;135(12):1552–1555. [PubMed]
  • Shapiro SK. Hypersexual behavior complicating levodopa (I-dopa) therapy. Minn Med. 1973 Jan;56(1):58–59. [PubMed]
  • Gorski RA, Gordon JH, Shryne JE, Southam AM. Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res. 1978 Jun 16;148(2):333–346. [PubMed]
  • Pardridge WM, Gorski RA, Lippe BM, Green R. Androgens and sexual behavior. Ann Intern Med. 1982 Apr;96(4):488–501. [PubMed]
  • BAUER HG. Endocrine and metabolic conditions related to pathology in the hypothalamus: a review. J Nerv Ment Dis. 1959 Apr;128(4):323–338. [PubMed]
  • MITCHELL W, FALCONER MA, HILL D. Epilepsy with fetishism relieved by temporal lobectomy. Lancet. 1954 Sep 25;267(6839):626–630. [PubMed]
  • Everitt BJ. Monoamines and the control of sexual behaviour. Psychol Med. 1983 Nov;13(4):715–720. [PubMed]
  • Clark JT, Smith ER, Davidson JM. Enhancement of sexual motivation in male rats by yohimbine. Science. 1984 Aug 24;225(4664):847–849. [PubMed]
  • MONEY J. Phantom orgasm in the dreams of paraplegic men and women. Arch Gen Psychiatry. 1960 Oct;3:373–382. [PubMed]
  • Nauta WJ. Neural associations of the frontal cortex. Acta Neurobiol Exp (Wars) 1972;32(2):125–140. [PubMed]

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