PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
J Neurol Neurosurg Psychiatry. 1986 August; 49(8): 853–860.
PMCID: PMC1028944

Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography.

Abstract

L-[18F] fluorodopa was administered in trace amounts intravenously to healthy control subjects and to patients with Parkinson's disease. Striatal uptake of radioactivity was measured using positron emission tomography. The capacity of the striatum to retain tracer was severely impaired in patients compared to controls. This may reflect a reduction of striatal dopamine storage in Parkinson's disease. Patients showing the "on/off" phenomenon had an even greater decrease of striatal storage capacity.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.4M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Leenders KL, Gibbs JM, Frackowiak RS, Lammertsma AA, Jones T. Positron emission tomography of the brain: new possibilities for the investigation of human cerebral pathophysiology. Prog Neurobiol. 1984;23(1-2):1–38. [PubMed]
  • Firnau G, Chirakal R, Garnett ES. Aromatic radiofluorination with [18F]fluorine gas: 6-[18F]fluoro-L-dopa. J Nucl Med. 1984 Nov;25(11):1228–1233. [PubMed]
  • Garnett S, Firnau G, Nahmias C, Chirakal R. Striatal dopamine metabolism in living monkeys examined by positron emission tomography. Brain Res. 1983 Nov 28;280(1):169–171. [PubMed]
  • Garnett ES, Firnau G, Nahmias C. Dopamine visualized in the basal ganglia of living man. Nature. 1983 Sep 8;305(5930):137–138. [PubMed]
  • Garnett ES, Nahmias C, Firnau G. Central dopaminergic pathways in hemiparkinsonism examined by positron emission tomography. Can J Neurol Sci. 1984 Feb;11(1 Suppl):174–179. [PubMed]
  • Phelps ME, Hoffman EJ, Huang SC, Kuhl DE. ECAT: a new computerized tomographic imaging system for positron-emitting radiopharmaceuticals. J Nucl Med. 1978 Jun;19(6):635–647. [PubMed]
  • Lieberman A, Dziatolowski M, Gopinathan G, Kupersmith M, Neophytides A, Korein J. Evaluation of Parkinson's disease. Adv Biochem Psychopharmacol. 1980;23:277–286. [PubMed]
  • Garnett ES, Firnau G, Nahmias C, Sood S, Belbeck L. Blood-brain barrier transport and cerebral utilization of dopa in living monkeys. Am J Physiol. 1980 May;238(5):R318–R327. [PubMed]
  • Garnett ES, Firnau G, Chan PK, Sood S, Belbeck LW. [18F]fluoro-dopa, an analogue of dopa, and its use in direct external measurements of storage, degradation, and turnover of intracerebral dopamine. Proc Natl Acad Sci U S A. 1978 Jan;75(1):464–467. [PubMed]
  • Firnau G, Garnett ES, Chan PK, Belbeck LW. Intracerebral dopamine metabolism studied by a novel radioisotope technique. J Pharm Pharmacol. 1976 Jul;28(7):584–585. [PubMed]
  • Horne MK, Cheng CH, Wooten GF. The cerebral metabolism of L-dihydroxyphenylalanine. An autoradiographic and biochemical study. Pharmacology. 1984;28(1):12–26. [PubMed]
  • Hefti F, Melamed E, Wurtman RJ. The site of dopamine formation in rat striatum after L-dopa administration. J Pharmacol Exp Ther. 1981 Apr;217(1):189–197. [PubMed]
  • Melamed E, Hefti F, Bitton V, Globus M. Suppression of L-dopa-induced circling in rats with nigral lesions by blockade of central dopa-decarboxylase: implications for mechanism of action of L-dopa in parkinsonism. Neurology. 1984 Dec;34(12):1566–1570. [PubMed]
  • Wooten GF, Horne MK. A new autoradiographic approach for imaging forebrain dopamine distribution. Ann Neurol. 1982 Aug;12(2):163–168. [PubMed]
  • Reches A, Fahn S. 3-O-methyldopa blocks dopa metabolism in rat corpus striatum. Ann Neurol. 1982 Sep;12(3):267–271. [PubMed]
  • Gervas JJ, Muradás V, Bazán E, Aguado EG, de Yébenes JG. Effects of 3-OM-dopa on monoamine metabolism in rat brain. Neurology. 1983 Mar;33(3):278–282. [PubMed]
  • Hardie RJ, Lees AJ, Stern GM. On-off fluctuations in Parkinson's disease. A clinical and neuropharmacological study. Brain. 1984 Jun;107(Pt 2):487–506. [PubMed]
  • Nutt JG, Woodward WR, Hammerstad JP, Carter JH, Anderson JL. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med. 1984 Feb 23;310(8):483–488. [PubMed]
  • Quinn N, Parkes JD, Marsden CD. Control of on/off phenomenon by continuous intravenous infusion of levodopa. Neurology. 1984 Sep;34(9):1131–1136. [PubMed]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group