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Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
J Neurol Neurosurg Psychiatry. 1985 February; 48(2): 157–159.
PMCID: PMC1028218

Intravenous methylprednisolone for multiple sclerosis in relapse.

Abstract

A randomised comparison is made between methylprednisolone, 1 g intravenously daily for 7 days, and a standard ACTH regime for the treatment of multiple sclerosis in acute relapse. It is found that methylprednisolone produces a more rapid clinical improvement than ACTH but confers no longer term benefit when the two treatments are compared at 3 months. It is proposed that intravenous methylprednisolone does have a role to play in the management of a patient with an acute relapse of multiple sclerosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Rose AS, Kuzma JW, Kurtzke JF, Namerow NS, Sibley WA, Tourtellotte WW. Cooperative study in the evaluation of therapy in multiple sclerosis. ACTH vs. placebo--final report. Neurology. 1970 May;20(5):1–59. [PubMed]
  • Millar JH, Vas CJ, Noronha MJ, Liversedge LA, Rawson MD. Long-term treatment of multiple sclerosis with corticotrophin. Lancet. 1967 Aug 26;2(7513):429–431. [PubMed]
  • Dowling PC, Bosch VV, Cook SD. Possible beneficial effect of high-dose intravenous steroid therapy in acute demyelinating disease and transverse myelitis. Neurology. 1980 Jul;30(7 Pt 2):33–36. [PubMed]
  • Buckley C, Kennard C, Swash M. Treatment of acute exacerbations of multiple sclerosis with intravenous methyl-prednisolone. J Neurol Neurosurg Psychiatry. 1982 Feb;45(2):179–180. [PMC free article] [PubMed]
  • KURTZKE JF. FURTHER NOTES ON DISABILITY EVALUATION IN MULTIPLE SCLEROSIS, WITH SCALE MODIFICATIONS. Neurology. 1965 Jul;15:654–661. [PubMed]
  • Trotter JL, Garvey WF. Prolonged effects of large-dose methylprednisolone infusion in multiple sclerosis. Neurology. 1980 Jul;30(7 Pt 1):702–708. [PubMed]

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