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J Neurol Neurosurg Psychiatry. 1984 September; 47(9): 960–964.
PMCID: PMC1027998

Does viloxazine have epileptogenic properties?

Abstract

Six cases of convulsive seizures occurring during treatment with viloxazine notified to the Committee on Safety of Medicines (CSM) and two other cases from Japan were reviewed. A critical study of the patient's histories suggests a possible causal connection between drug and seizures in only two of these cases. The occurrence of convulsions is not in keeping with the results of animal experiments and of clinical trials in which epileptic patients were included, both of which suggest that viloxazine does not have epileptogenic properties and may have anticonvulsant actions. A worldwide review of clinical trials in which unwanted effects have been recorded suggests that viloxazine, even if possessing convulsive properties like other anti-depressants, is probably less epileptogenic than conventional tricyclics and is not contraindicated in epileptic patients requiring antidepressant medication.

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Selected References

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  • Mallion KB, Todd AH, Turner RW, Bainbridge JG, Greenwood DT, Madinaveitia J, Somerville AR, Whittle BA. 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine hydrochloride, a potential psychotropic agent. Nature. 1972 Jul 21;238(5360):157–158. [PubMed]
  • Edwards JG. Convulsive seizures and viloxazine. Br Med J. 1977 Jul 9;2(6079):96–97. [PMC free article] [PubMed]
  • Magnus RV. A placebo controlled trial of viloxazine with and without tranquillizers in depressive illness. J Int Med Res. 1975;3(3):207–213. [PubMed]
  • Edwards JG. Antidepressants and convulsions. Lancet. 1979 Dec 22;2(8156-8157):1368–1369. [PubMed]
  • Meldrum BS, Anlezark GM, Adam HK, Greenwood DT. Anticonvulsant and proconvulsant properties of viloxazine hydrochloride: pharmacological and pharmacokinetic studies in rodents and the epileptic baboon. Psychopharmacology (Berl) 1982;76(3):212–217. [PubMed]
  • Neal H, Bradley PB. Electrophysiological studies with a new anti-depressant drug: comparison of the effects of viloxazine (ICI 58,834) with three tricyclic anti-depressants in the encéphale isolé. Neuropharmacology. 1978 Oct;17(10):835–849. [PubMed]
  • Neal H, Bradley PB. Electrocortical changes in the encéphale isolé cat following chronic treatment with antidepressant drugs. Neuropharmacology. 1979 Jul;18(7):611–615. [PubMed]
  • Tartara A, Bo P, Maurelli M, Savoldi F, Manzo L. EEG profile of the anticonvulsant action of viloxazine in the rabbit. Farmaco Sci. 1983 Mar;28(3):161–166. [PubMed]
  • Fontan M, Goudemand M, Pellerin-Millecamps E. Expérimentation clinique de la viloxazine dans les états dépressifs. Encephale. 1979;5(3):243–249. [PubMed]
  • Inman WH, Vessey MP. Investigation of deaths from pulmonary, coronary, and cerebral thrombosis and embolism in women of child-bearing age. Br Med J. 1968 Apr 27;2(5599):193–199. [PMC free article] [PubMed]
  • Dunlop D. The use and abuse of psychotrophic drugs. Scott Med J. 1971 Aug;16(8):345–349. [PubMed]
  • Edwards JG. Viloxazine: assessment of potential rapid antidepressant action. Br Med J. 1977 Nov 19;2(6098):1327–1327. [PMC free article] [PubMed]
  • Hollister LE. Valium: a discussion of current issues. Psychosomatics. 1977;18(1):44–58. [PubMed]
  • Alkalay D, Wagner WE, Jr, Carlsen S, Khemani L, Volk J, Bartlett MF, LeSher A. Bioavailability and kinetics of maprotiline. Clin Pharmacol Ther. 1980 May;27(5):697–703. [PubMed]
  • Edwards JG, Alexander JR, Alexander MS, Gordon A, Zutchi T. Controlled trial of sulpiride in chronic schizophrenic patients. Br J Psychiatry. 1980 Dec;137:522–529. [PubMed]
  • Weissman MM, Klerman GL. Sex differences and the epidemiology of depression. Arch Gen Psychiatry. 1977 Jan;34(1):98–111. [PubMed]
  • Jick H, Dinan BJ, Hunter JR, Stergachis A, Ronning A, Perera DR, Madsen S, Nudelman PM. Tricyclic antidepressants and convulsions. J Clin Psychopharmacol. 1983 Jun;3(3):182–185. [PubMed]
  • Peck AW, Stern WC, Watkinson C. Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion. J Clin Psychiatry. 1983 May;44(5 Pt 2):197–201. [PubMed]

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