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Br Heart J. 1992 December; 68(6): 608–612.
PMCID: PMC1025693

Adjustment for the influence of age and heart rate on Doppler measurements of left ventricular filling

Abstract

Objective—To determine the normal range of pulsed Doppler measurements of left ventricular filling adjusted for age and heart rate.

Design—Multiple regression was used to measure the effects of age and heart rate on pulsed Doppler indices of left ventricular filling in normal subjects. These regression equations were used to calculate a predicted normal value and 95% confidence interval (95% CI) for any subject from his age and heart rate.

Participants—61 subjects with no evidence of cardiovascular disease, aged 20 to 90 years, with a resting heart rate of 47–89 beats/min.

Results—The effect of a 10 year increase in age was peak atrial filling velocity +15% (95% CI 12·0% to 18·5%); peak early filling velocity −3·2% (−6·0% to 0%); isovolumic relaxation time +6·2% (3·9% to 8·4%); acceleration time −3·8% (−6·0% to −1·5%); deceleration time +7·9% (5·1% to 10·8%). The effect of a 10 beat/min increase in heart rate was: peak atrial filling velocity +5·5% (1·2% to 10·1%); peak early filling velocity −4·0% (−8·1% to 2·0%); isovolumic relaxation time −2·5% (−4·6% to 0·6%); acceleration time −3·1% (−6·4% to 0·4%); decleration time −1·8% (−4·0% to 3·8%).

Conclusion—For any individual, comparison of the predicted normal measurement and 95% CI with the observed measurement allows an assessment of the effects of disease on left ventricular filling that is independent of age and heart rate.

Full text

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Spirito P, Maron BJ. Doppler echocardiography for assessing left ventricular diastolic function. Ann Intern Med. 1988 Jul 15;109(2):122–126. [PubMed]
  • Harizi RC, Bianco JA, Alpert JS. Diastolic function of the heart in clinical cardiology. Arch Intern Med. 1988 Jan;148(1):99–109. [PubMed]
  • Van Dam I, Fast J, de Boo T, Hopman J, Van Oort A, Heringa A, Alsters J, Van Der Werf T, Daniëls O. Normal diastolic filling patterns of the left ventricle. Eur Heart J. 1988 Feb;9(2):165–171. [PubMed]
  • Bryg RJ, Williams GA, Labovitz AJ. Effect of aging on left ventricular diastolic filling in normal subjects. Am J Cardiol. 1987 Apr 15;59(9):971–974. [PubMed]
  • Miller TR, Grossman SJ, Schectman KB, Biello DR, Ludbrook PA, Ehsani AA. Left ventricular diastolic filling and its association with age. Am J Cardiol. 1986 Sep 1;58(6):531–535. [PubMed]
  • Miyatake K, Okamoto M, Kinoshita N, Owa M, Nakasone I, Sakakibara H, Nimura Y. Augmentation of atrial contribution to left ventricular inflow with aging as assessed by intracardiac Doppler flowmetry. Am J Cardiol. 1984 Feb 1;53(4):586–589. [PubMed]
  • Spirito P, Maron BJ. Influence of aging on Doppler echocardiographic indices of left ventricular diastolic function. Br Heart J. 1988 Jun;59(6):672–679. [PMC free article] [PubMed]
  • Smith SA, Stoner JE, Russell AE, Sheppard JM, Aylward PE. Transmitral velocities measured by pulsed Doppler in healthy volunteers: effects of acute changes in blood pressure and heart rate. Br Heart J. 1989 Apr;61(4):344–347. [PMC free article] [PubMed]
  • Bianco JA, Filiberti AW, Baker SP, King MA, Nalivaika LA, Leahey D, Doherty PW, Alpert JS. Ejection fraction and heart rate correlate with diastolic peak filling rate at rest and during exercise. Chest. 1985 Jul;88(1):107–113. [PubMed]
  • Lavine SJ, Krishnaswami V, Levinson N, Shaver JA. Effect of heart rate alterations produced by atrial pacing on the pattern of diastolic filling in normal subjects. Am J Cardiol. 1988 Nov 15;62(16):1098–1102. [PubMed]
  • Uiterwaal C, Van Dam I, De Boo T, Van Keulen P, Folgering H, Hopman J, Daniels O. The effect of respiration on diastolic blood flow velocities in the human heart. Eur Heart J. 1989 Feb;10(2):108–112. [PubMed]
  • Wallmeyer K, Wann LS, Sagar KB, Kalbfleisch J, Klopfenstein HS. The influence of preload and heart rate on Doppler echocardiographic indexes of left ventricular performance: comparison with invasive indexes in an experimental preparation. Circulation. 1986 Jul;74(1):181–186. [PubMed]
  • Plotnick GD, Kahn B, Rogers WJ, Fisher ML, Becker LC. Effect of postural changes, nitroglycerin and verapamil on diastolic ventricular function as determined by radionuclide angiography in normal subjects. J Am Coll Cardiol. 1988 Jul;12(1):121–129. [PubMed]
  • Finkelhor RS, Hanak LJ, Bahler RC. Left ventricular filling in endurance-trained subjects. J Am Coll Cardiol. 1986 Aug;8(2):289–293. [PubMed]
  • Kuecherer H, Ruffmann K, Kuebler W. Effect of aging on Doppler echocardiographic filling parameters in normal subjects and in patients with coronary artery disease. Clin Cardiol. 1988 May;11(5):303–306. [PubMed]
  • Lew AS, Hod H, Cercek B, Shah PK, Ganz W. Mortality and morbidity rates of patients older and younger than 75 years with acute myocardial infarction treated with intravenous streptokinase. Am J Cardiol. 1987 Jan 1;59(1):1–5. [PubMed]
  • Jaffe WM, Dewhurst TA, Otto CM, Pearlman AS. Influence of Doppler sample volume location on ventricular filling velocities. Am J Cardiol. 1991 Aug 15;68(5):550–552. [PubMed]

Articles from British Heart Journal are provided here courtesy of BMJ Group