Search tips
Search criteria 


Logo of brheartjLink to Publisher's site
Br Heart J. 1992 December; 68(6): 560–566.
PMCID: PMC1025685

Effect of exercise training on the total ischaemic burden: an assessment by 24 hour ambulatory electrocardiographic monitoring


Objective—To examine the effect of prolonged high intensity exercise training on total ischaemic burden in men with chronic stable angina pectoris.

Design—A randomised controlled trial based on 24 hour ambulatory electrocardiographic monitoring of patients on two occasions a year apart.

Setting—Cardiology department of a large general hospital.

Subjects—40 men under 60 years of age with chronic stable angina pectoris and no previous myocardial infarction.

Results—After training the exercise group showed a 30% reduction in frequency of ST segment depression. There were significant reductions in painful episodes of ischaemia and those triggered by changes in heart rate. There was also a trend towards a reduction in silent ischaemia and episodes not triggered by changes in heart rate. The duration of ischaemic episodes was also reduced. No significant change in frequency or severity of dysrhythmia was shown.

Conclusions—Exercise training reduces total ischaemic burden in patients with angina pectoris by reducing the frequency and duration of all types of ischaemic episode.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Balasubramanian V, Lahiri A, Green HL, Stott FD, Raftery EB. Ambulatory ST segment monitoring. Problems, pitfalls, solutions, and clinical application. Br Heart J. 1980 Oct;44(4):419–425. [PMC free article] [PubMed]
  • Deanfield JE, Maseri A, Selwyn AP, Ribeiro P, Chierchia S, Krikler S, Morgan M. Myocardial ischaemia during daily life in patients with stable angina: its relation to symptoms and heart rate changes. Lancet. 1983 Oct 1;2(8353):753–758. [PubMed]
  • Cecchi AC, Dovellini EV, Marchi F, Pucci P, Santoro GM, Fazzini PF. Silent myocardial ischemia during ambulatory electrocardiographic monitoring in patients with effort angina. J Am Coll Cardiol. 1983 Mar;1(3):934–939. [PubMed]
  • Todd IC, Ballantyne D. Antianginal efficacy of exercise training: a comparison with beta blockade. Br Heart J. 1990 Jul;64(1):14–19. [PMC free article] [PubMed]
  • Lown B. Sudden cardiac death -- 1978. Circulation. 1979 Dec;60(7):1593–1599. [PubMed]
  • Quyyumi AA, Wright C, Mockus L, Fox KM. Effect of partial agonist activity in beta blockers in severe angina pectoris: a double blind comparison of pindolol and atenolol. Br Med J (Clin Res Ed) 1984 Oct 13;289(6450):951–953. [PMC free article] [PubMed]
  • Subramanian B, Bowles MJ, Davies AB, Raftery EB. Combined therapy with verapamil and propranolol in chronic stable angina. Am J Cardiol. 1982 Jan;49(1):125–132. [PubMed]
  • Knoebel SB. President's page: On the occasion of the 25th year of the Journal of the American College of Cardiology. J Am Coll Cardiol. 1983 Jan;1(1):1–2. [PubMed]
  • Subramanian VB, Bowles MJ, Khurmi NS, Davies AB, Raftery EB. Randomized double-blind comparison of verapamil and nifedipine in chronic stable angina. Am J Cardiol. 1982 Oct;50(4):696–703. [PubMed]
  • Schreiber TL, Miller DH, Silvasi DA, Moses JW, Borer JS. Randomized double-blind trial of intravenous streptokinase for acute myocardial infarction. Am J Cardiol. 1986 Jul 1;58(1):47–52. [PubMed]
  • Chierchia S, Gallino A, Smith G, Deanfield J, Morgan M, Croom M, Maseri A. Role of heart rate in pathophysiology of chronic stable angina. Lancet. 1984 Dec 15;2(8416):1353–1357. [PubMed]
  • Hinkle LE, Jr, Carver ST, Stevens M. The frequency of asymptomatic disturbances of cardiac rhythm and conduction in middle-aged men. Am J Cardiol. 1969 Nov;24(5):629–650. [PubMed]
  • Ryan M, Lown B, Horn H. Comparison of ventricular ectopic activity during 24-hour monitoring and exercise testing in patients with coronary heart disease. N Engl J Med. 1975 Jan 30;292(5):224–229. [PubMed]
  • Calvert A, Lown B, Gorlin R. Ventricular premature beats and anatomically defined coronary heart disease. Am J Cardiol. 1977 May 4;39(5):627–634. [PubMed]
  • Morganroth J, Michelson EL, Horowitz LN, Josephson ME, Pearlman AS, Dunkman WB. Limitations of routine long-term electrocardiographic monitoring to assess ventricular ectopic frequency. Circulation. 1978 Sep;58(3 Pt 1):408–414. [PubMed]

Articles from British Heart Journal are provided here courtesy of BMJ Group