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Br Heart J. 1993 May; 69(5): 391–394.
PMCID: PMC1025099

Anticardiolipin antibodies in ischaemic heart disease: marker or myth?


OBJECTIVES--To assess the incidence and significance of anticardiolipin antibodies after myocardial infarction and in unstable angina. DESIGN--A prospective study of all patients under 60 admitted to the coronary care unit over a 12 month period with a diagnosis of acute myocardial infarction who were followed up for a further 12 months. Patients admitted with unstable angina were similarly assessed but not followed up. Anticardiolipin antibody concentrations were compared with those of age matched controls. SETTING--A district general hospital. PATIENTS--307 patients with acute myocardial infarction and 160 patients with unstable angina. RESULTS--Anticardiolipin antibody concentrations in the two patient groups did not differ significantly from those in the control groups. Antibody concentrations were not related to a history of angina or myocardial infarction nor were they related to subsequent cardiovascular complications. CONCLUSION--This study shows no significant association between anticardiolipin antibody concentrations and either myocardial infarction or unstable angina.

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Selected References

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  • Hamsten A, Norberg R, Björkholm M, de Faire U, Holm G. Antibodies to cardiolipin in young survivors of myocardial infarction: an association with recurrent cardiovascular events. Lancet. 1986 Jan 18;1(8473):113–116. [PubMed]
  • Klemp P, Cooper RC, Strauss FJ, Jordaan ER, Przybojewski JZ, Nel N. Anti-cardiolipin antibodies in ischaemic heart disease. Clin Exp Immunol. 1988 Nov;74(2):254–257. [PubMed]
  • Morton KE, Gavaghan TP, Krilis SA, Daggard GE, Baron DW, Hickie JB, Chesterman CN. Coronary artery bypass graft failure--an autoimmune phenomenon? Lancet. 1986 Dec 13;2(8520):1353–1357. [PubMed]
  • Harris EN, Asherson RA, Hughes GR. Antiphospholipid antibodies--autoantibodies with a difference. Annu Rev Med. 1988;39:261–271. [PubMed]
  • Asherson RA, Mackay IR, Harris EN. Myocardial infarction in a young man with systemic lupus erythematosus, deep vein thrombosis, and antibodies to phospholipid. Br Heart J. 1986 Aug;56(2):190–193. [PMC free article] [PubMed]
  • Sletnes KE, Smith P, Abdelnoor M, Arnesen H, Wisløff F. Antiphospholipid antibodies after myocardial infarction and their relation to mortality, reinfarction, and non-haemorrhagic stroke. Lancet. 1992 Feb 22;339(8791):451–453. [PubMed]
  • Meroni PL, Harris EN, Brucato A, Tincani A, Barcellini W, Vismara A, Balestrieri G, Hughes GR, Zanussi C. Anti-mitochondrial type M5 and anti-cardiolipin antibodies in autoimmune disorders: studies on their association and cross-reactivity. Clin Exp Immunol. 1987 Mar;67(3):484–491. [PubMed]
  • Loizou S, McCrea JD, Rudge AC, Reynolds R, Boyle CC, Harris EN. Measurement of anti-cardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results. Clin Exp Immunol. 1985 Dec;62(3):738–745. [PubMed]
  • Harris EN, Gharavi AE, Patel SP, Hughes GR. Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986. Clin Exp Immunol. 1987 Apr;68(1):215–222. [PubMed]
  • Harris EN, Hughes GR. Standardising the anti-cardiolipin antibody test. Lancet. 1987 Jan 31;1(8527):277–277. [PubMed]

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