Search tips
Search criteria 


Logo of brheartjLink to Publisher's site
Br Heart J. 1991 November; 66(5): 359–363.
PMCID: PMC1024774

Estimating the size of myocardial infarction by magnetic resonance imaging.


OBJECTIVE--To develop a method to measure myocardial infarct size by magnetic resonance imaging and to compare the results with pyrophosphate scanning by single photon emission computed tomography. DESIGN--All patients underwent magnetic resonance imaging and pyrophosphate scanning 5-7 days after the onset of symptoms. Both measurements of infarct size were compared with the release of creatine kinase MB and with ventricular performance estimated by radionuclide ventriculography. PATIENTS--19 patients (age 40-68 years) who had sustained their first uncomplicated myocardial infarction and who had not been treated with thrombolytic therapy. RESULTS--The site of infarction was clearly shown by both imaging techniques and was identical in each patient. The volume of infarcted tissue measured by magnetic resonance imaging agreed well with the infarct size measured by single photon emission tomography (mean difference 2.7 cm3). Correlations of both imaging techniques with the release of creatine kinase MB were best when total release rather than peak release was used. Both imaging techniques correlated closely with the subsequent ventricular performance. CONCLUSIONS--Magnetic resonance imaging after acute infarction allows measurement of infarct size and this may prove useful in assessing new treatments designed to salvage myocardium.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.4M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • White HD, Norris RM, Brown MA, Takayama M, Maslowski A, Bass NM, Ormiston JA, Whitlock T. Effect of intravenous streptokinase on left ventricular function and early survival after acute myocardial infarction. N Engl J Med. 1987 Oct 1;317(14):850–855. [PubMed]
  • Rokey R, Verani MS, Bolli R, Kuo LC, Ford JJ, Wendt RE, Schneiders NJ, Bryan RN, Roberts R. Myocardial infarct size quantification by MR imaging early after coronary artery occlusion in dogs. Radiology. 1986 Mar;158(3):771–774. [PubMed]
  • Caputo GR, Sechtem U, Tscholakoff D, Higgins CB. Measurement of myocardial infarct size at early and late time intervals using MR imaging: an experimental study in dogs. AJR Am J Roentgenol. 1987 Aug;149(2):237–243. [PubMed]
  • Been M, Smith MA, Ridgeway JP, Brydon JW, Douglas RH, Kean DM, Best JJ, Muir AL. Characterisation of acute myocardial infarction by gated magnetic resonance imaging. Lancet. 1985 Aug 17;2(8451):348–350. [PubMed]
  • Tscholakoff D, Higgins CB, Sechtem U, Caputo G, Derugin N. MRI of reperfused myocardial infarct in dogs. AJR Am J Roentgenol. 1986 May;146(5):925–930. [PubMed]
  • Jansen DE, Corbett JR, Wolfe CL, Lewis SE, Gabliani G, Filipchuk N, Redish G, Parkey RW, Buja LM, Jaffe AS, et al. Quantification of myocardial infarction: a comparison of single photon-emission computed tomography with pyrophosphate to serial plasma MB-creatine kinase measurements. Circulation. 1985 Aug;72(2):327–333. [PubMed]
  • Muir AL, Hannan WJ, Sapru RP, Boardman AK, Wraith PK, Brash HM. The effects of isoprenaline, atropine and dobutamine on ventricular volume curves obtained by radionuclide ventriculography. Clin Sci (Lond) 1980 May;58(5):357–364. [PubMed]
  • Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307–310. [PubMed]
  • Uniform requirements for manuscripts submitted to biomedical journals: International Committee of Medical Journal Editors. Br Heart J. 1983 Jan;49(1):1–7. [PMC free article] [PubMed]
  • Page DL, Caulfield JB, Kastor JA, DeSanctis RW, Sanders CA. Myocardial changes associated with cardiogenic shock. N Engl J Med. 1971 Jul 15;285(3):133–137. [PubMed]
  • Alonso DR, Scheidt S, Post M, Killip T. Pathophysiology of cardiogenic shock. Quantification of myocardial necrosis, clinical, pathologic and electrocardiographic correlations. Circulation. 1973 Sep;48(3):588–596. [PubMed]
  • Shell WE, Kjekshus JK, Sobel BE. Quantitative assessment of the extent of myocardial infarction in the conscious dog by means of analysis of serial changes in serum creatine phosphokinase activity. J Clin Invest. 1971 Dec;50(12):2614–2625. [PMC free article] [PubMed]
  • Kluge WF. Prognostic value of serum creatine phosphokinase levels in myocardial infarction. Northwest Med. 1969 Sep;68(9):847–853. [PubMed]
  • Muller JE, Maroko PR, Braunwald E. Evaluation of precordial electrocardiographic mapping as a means of assessing changes in myocardial ischemic injury. Circulation. 1975 Jul;52(1):16–27. [PubMed]
  • Murray RG, Peshock RM, Parkey RW, Bonte FJ, Willerson JT, Blomqvist CG. ST isopotential precordial surface maps in patients with acute myocardial infarction. J Electrocardiol. 1979 Jan;12(1):55–64. [PubMed]
  • Corbett JR, Lewis M, Willerson JT, Nicod PH, Huxley RL, Simon T, Rude RE, Henderson E, Parkey R, Rellas JS, et al. 99mTc-pyrophosphate imaging in patients with acute myocardial infarction: comparison of planar imaging with single-photon tomography with and without blood pool overlay. Circulation. 1984 Jun;69(6):1120–1128. [PubMed]
  • Lewis SE, Devous MD, Sr, Corbett JR, Izquierdo C, Nicod P, Wolfe CL, Parkey RW, Buja LM, Willerson JT. Measurement of infarct size in acute canine myocardial infarction by single-photon emission computed tomography with technetium-99m pyrophosphate. Am J Cardiol. 1984 Jul 1;54(1):193–199. [PubMed]
  • Buja LM, Parkey RW, Stokely EM, Bonte FJ, Willerson JT. Pathophysiology of technetium-99m stannous pyrophosphate and thallium-201 scintigraphy of acute anterior myocardial infarcts in dogs. J Clin Invest. 1976 Jun;57(6):1508–1522. [PMC free article] [PubMed]
  • Been M, Smith MA, Ridgway JP, Douglas RH, de Bono DP, Best JJ, Muir AL. Serial changes in the T1 magnetic relaxation parameter after myocardial infarction in man. Br Heart J. 1988 Jan;59(1):1–8. [PMC free article] [PubMed]
  • Brown JJ, Higgins CB. Myocardial paramagnetic contrast agents for MR imaging. AJR Am J Roentgenol. 1988 Nov;151(5):865–871. [PubMed]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group