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Br Heart J. 1991 May; 65(5): 245–248.
PMCID: PMC1024624

Oxygen free radicals and congestive heart failure.

Abstract

Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive heart failure (median 420 mumol/l (IQR 379-480)) than in the controls (median 463 mumol/l (IQR 445-525)). There was a significant but weak negative correlation between malondialdehyde and left ventricular ejection fraction (r = -0.35) and a positive correlation between plasma thiols and left ventricular ejection fraction (r = 0.39). This study provides clinical support for experimental data indicating that free radicals may be important in heart failure. It also suggests that the degree of free radical production may be linked to the severity of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Packer M. Sudden unexpected death in patients with congestive heart failure: a second frontier. Circulation. 1985 Oct;72(4):681–685. [PubMed]
  • McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985 Jan 17;312(3):159–163. [PubMed]
  • Belch JJ, Chopra M, Hutchison S, Lorimer R, Sturrock RD, Forbes CD, Smith WE. Free radical pathology in chronic arterial disease. Free Radic Biol Med. 1989;6(4):375–378. [PubMed]
  • Goodman J, Hochstein P. Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin. Biochem Biophys Res Commun. 1977 Jul 25;77(2):797–803. [PubMed]
  • Graham DG, Tiffany SM, Bell WR, Jr, Gutknecht WF. Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Mol Pharmacol. 1978 Jul;14(4):644–653. [PubMed]
  • ELLMAN GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959 May;82(1):70–77. [PubMed]
  • Hammermeister KE, DeRouen TA, Dodge HT. Variables predictive of survival in patients with coronary disease. Selection by univariate and multivariate analyses from the clinical, electrocardiographic, exercise, arteriographic, and quantitative angiographic evaluations. Circulation. 1979 Mar;59(3):421–430. [PubMed]
  • Jennings PE, Jones AF, Florkowski CM, Lunec J, Barnett AH. Increased diene conjugates in diabetic subjects with microangiopathy. Diabet Med. 1987 Sep-Oct;4(5):452–456. [PubMed]
  • Lunec J, Halloran SP, White AG, Dormandy TL. Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis. J Rheumatol. 1981 Mar-Apr;8(2):233–245. [PubMed]
  • Rosen GM, Rauckman EJ. Spin trapping of superoxide and hydroxyl radicals. Methods Enzymol. 1984;105:198–209. [PubMed]
  • Banford JC, Brown DH, Hazelton RA, McNeil CJ, Smith WE, Sturrock RD. Altered thiol status in patients with rheumatoid arthritis. Rheumatol Int. 1982;2(3):107–111. [PubMed]
  • Guarnieri C, Flamigni F, Caldarera CM. Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart. J Mol Cell Cardiol. 1980 Aug;12(8):797–808. [PubMed]
  • Hess ML, Okabe E, Kontos HA. Proton and free oxygen radical interaction with the calcium transport system of cardiac sarcoplasmic reticulum. J Mol Cell Cardiol. 1981 Aug;13(8):767–772. [PubMed]
  • Chopra M, Scott N, McMurray J, McLay J, Bridges A, Smith WE, Belch JJ. Captopril: a free radical scavenger. Br J Clin Pharmacol. 1989 Mar;27(3):396–399. [PubMed]
  • Chopra M, McMurray J, McLay J, Bridges A, Scott N, Smith WE, Belch JJ. Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging? Adv Exp Med Biol. 1990;264:251–255. [PubMed]

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