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J Clin Pathol. 1999 May; 52(5): 388–389.
PMCID: PMC1023079

Eosinophilic myelodysplasia transforming to acute lymphoblastic leukaemia.

Abstract

A 43 year old male presented with a marked eosinophilia and associated systemic symptoms. A diagnosis of myelodysplasia was made on the basis of bone marrow morphology and karyotype. Over a 12 month period the disease transformed into acute lymphoblastic leukaemia, confirmed by flow cytometry, cytochemistry, and immunohistochemistry. Karyotyping was abnormal with 5q- and -7 which persisted from diagnosis through to blastic transformation. He died following initial induction chemotherapy. Eosinophilic myelodysplasia is an uncommon condition in haematological practice and no previous report of lymphoblastic transformation has been found.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Viniou N, Yataganas X, Abazis D, Paterakis G, Vavourakis S, Stamatopoulos K, Matzourani M, Loukopoulos D, Pangalos C. Hypereosinophilia associated with monosomy 7. Cancer Genet Cytogenet. 1995 Mar;80(1):68–71. [PubMed]
  • Keene P, Mendelow B, Pinto MR, Bezwoda W, MacDougall L, Falkson G, Ruff P, Bernstein R. Abnormalities of chromosome 12p13 and malignant proliferation of eosinophils: a nonrandom association. Br J Haematol. 1987 Sep;67(1):25–31. [PubMed]
  • Troxell ML, Mills GM, Allen RC. The hypereosinophilic syndrome in acute lymphocytic leukemia. Cancer. 1984 Sep 15;54(6):1058–1061. [PubMed]
  • Takai K, Sanada M. Hypereosinophilic syndrome evolving to acute lymphoblastic leukemia. Int J Hematol. 1991 Jun;54(3):231–239. [PubMed]
  • Blatt J, Proujansky R, Horn M, Phebus C, Longworth D, Penchansky L. Idiopathic hypereosinophilic syndrome terminating in acute lymphoblastic leukemia. Pediatr Hematol Oncol. 1992 Apr-Jun;9(2):151–155. [PubMed]
  • Matsushima T, Murakami H, Sawamura M, Tamura J, Sakura T, Matsumoto M, Hirabayashi H, Miyawaki S, Simano S, Sato S, et al. Myelodysplastic syndrome with eosinophilia in bone marrow. Gunma Haematology Study Group. Br J Haematol. 1993 Aug;84(4):636–638. [PubMed]

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