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J Neurol Neurosurg Psychiatry. 1993 July; 56(7): 793–798.
PMCID: PMC1015062

MRI in 31 patients with Behçet's disease and neurological involvement: prospective study with clinical correlation.


Thirty one patients with Behçet's disease and neurological manifestations were prospectively studied with MRI. Cerebral venous thrombosis was diagnosed in 10 patients. MRI performed during the acute illness in eight patients showed an abnormally high signal on the T2 weighted sequences in the occluded sinus. MRI showed minor flow abnormalities suggestive of partial recanalisation of the sinus in two cases at a later clinical stage. MRI can be an alternative, non-invasive, investigation to intravenous cerebral angiography. In 13 patients with central nervous system involvement, MRI performed during the acute illness showed multiple hyperintense lesions on T2 weighted sequences. They were usually less than 5 mm, scattered and confluent, mainly in the white matter, distributed in the hemispheric white matter in nine cases, brainstem in eight, basal ganglia and thalamus in five, and cortex in two. MRI abnormalities were usually associated with appropriate clinical deficits, but were larger and more disseminated than expected.

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  • Kawakita H, Nishimura M, Satoh Y, Shibata N. Neurological aspects of Behçet's disease. A case report and clinico-pathological review of the literature in Japan. J Neurol Sci. 1967 Nov-Dec;5(3):417–439. [PubMed]
  • Lakhanpal S, Tani K, Lie JT, Katoh K, Ishigatsubo Y, Ohokubo T. Pathologic features of Behçet's syndrome: a review of Japanese autopsy registry data. Hum Pathol. 1985 Aug;16(8):790–795. [PubMed]
  • SCHOTLAND DL, WOLF SM, WHITE HH, DUBIN HV. Neurologic aspects of Behcet's disease. Case report and review of the literature. Am J Med. 1963 Apr;34:544–553. [PubMed]
  • Willeit J, Schmutzhard E, Aichner F, Mayr U, Weber F, Gerstenbrand F. CT and MR imaging in neuro-Behçet disease. J Comput Assist Tomogr. 1986 Mar-Apr;10(2):313–315. [PubMed]
  • Chajek T, Fainaru M. Behçet's disease. Report of 41 cases and a review of the literature. Medicine (Baltimore) 1975 May;54(3):179–196. [PubMed]
  • Patel DV, Neuman MJ, Hier DB. Reversibility of CT and MR findings in neuro-Behçet disease. J Comput Assist Tomogr. 1989 Jul-Aug;13(4):669–673. [PubMed]
  • Besana C, Comi G, Del Maschio A, Praderio L, Vergani A, Medaglini S, Martinelli V, Triulzi F, Locatelli T. Electrophysiological and MRI evaluation of neurological involvement in Behçet's disease. J Neurol Neurosurg Psychiatry. 1989 Jun;52(6):749–754. [PMC free article] [PubMed]
  • Fukuyama H, Kameyama M, Nabatame H, Takemura M, Nishimura K, Fujisawa I, Torizuka K. Magnetic resonance images of neuro-Behçet syndrome show precise brain stem lesions. Report of a case. Acta Neurol Scand. 1987 Jan;75(1):70–73. [PubMed]
  • Kataoka S, Hirose G, Tsukada K. Brain stem type neuro-Behçet's syndrome. Correlation of enhanced CT scans and MRI during the acute and chronic stage of the illness. Neuroradiology. 1989;31(3):258–262. [PubMed]
  • Kermode AG, Plant GT, MacManus DG, Kendall BE, Kingsley DP, Moseley IF. Behçet's disease with slowly enlarging midbrain mass on MRI: resolution following steroid therapy. Neurology. 1989 Sep;39(9):1251–1252. [PubMed]
  • Miller DH, Ormerod IE, Gibson A, du Boulay EP, Rudge P, McDonald WI. MR brain scanning in patients with vasculitis: differentiation from multiple sclerosis. Neuroradiology. 1987;29(3):226–231. [PubMed]
  • Shakir RA, Sulaiman K, Kahn RA, Rudwan M. Neurological presentation of neuro-Behçet's syndrome: clinical categories. Eur Neurol. 1990;30(5):249–253. [PubMed]
  • Snyder TC, Sachdev HS. MR imaging of cerebral dural sinus thrombosis. J Comput Assist Tomogr. 1986 Sep-Oct;10(5):889–891. [PubMed]
  • Wechsler B, Vidailhet M, Piette JC, Bousser MG, Dell Isola B, Blétry O, Godeau P. Cerebral venous thrombosis in Behçet's disease: clinical study and long-term follow-up of 25 cases. Neurology. 1992 Mar;42(3 Pt 1):614–618. [PubMed]
  • O'Duffy JD, Goldstein NP. Neurologic involvement in seven patients with Behçet's disease. Am J Med. 1976 Aug;61(2):170–178. [PubMed]
  • Shimizu T, Ehrlich GE, Inaba G, Hayashi K. Behçet disease (Behçet syndrome). Semin Arthritis Rheum. 1979 May;8(4):223–260. [PubMed]
  • Kozin F, Haughton V, Bernhard GC. Neuro-Behcet disease: two cases and neuroradiologic findings. Neurology. 1977 Dec;27(12):1148–1152. [PubMed]
  • Rougemont D, Bousser MG, Wechsler B, Bletry O, Castaigne P, Godeau P. Manifestations neurologiques de la maladie de Behçet. Vingt-quatre observations. Rev Neurol (Paris) 1982;138(6-7):493–505. [PubMed]
  • Bousser MG, Chiras J, Bories J, Castaigne P. Cerebral venous thrombosis--a review of 38 cases. Stroke. 1985 Mar-Apr;16(2):199–213. [PubMed]
  • Macchi PJ, Grossman RI, Gomori JM, Goldberg HI, Zimmerman RA, Bilaniuk LT. High field MR imaging of cerebral venous thrombosis. J Comput Assist Tomogr. 1986 Jan-Feb;10(1):10–15. [PubMed]
  • McMurdo SK, Jr, Brant-Zawadzki M, Bradley WG, Jr, Chang GY, Berg BO. Dural sinus thrombosis: study using intermediate field strength MR imaging. Radiology. 1986 Oct;161(1):83–86. [PubMed]
  • Ormerod IE, Miller DH, McDonald WI, du Boulay EP, Rudge P, Kendall BE, Moseley IF, Johnson G, Tofts PS, Halliday AM, et al. The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. A quantitative study. Brain. 1987 Dec;110(Pt 6):1579–1616. [PubMed]
  • Bank I, Weart C. Dural sinus thrombosis in Behçet's disease. Arthritis Rheum. 1984 Jul;27(7):816–818. [PubMed]
  • Ben-Itzhak J, Keren S, Simon J. Intracranial venous thrombosis in Behcet's syndrome. Neuroradiology. 1985;27(5):450–450. [PubMed]
  • Brissaud P, Laroche L, de Gramont A, Krulik M. Digital angiography for the diagnosis of dural sinus thrombosis in Behçet's disease. Arthritis Rheum. 1985 Mar;28(3):359–360. [PubMed]
  • Feuilhade C, Touboul JL, Wechsler B, Guillard A. Thrombophlébite cérébrale av cours de la maladie de Behqet. Nouv Presse Med. 1982 Nov 13;11(45):3351–3351. [PubMed]
  • Harper CM, Jr, O'Neill BP, O'Duffy JD, Forbes GS. Intracranial hypertension in Behçet's disease: demonstration of sinus occlusion with use of digital subtraction angiography. Mayo Clin Proc. 1985 Jun;60(6):419–422. [PubMed]
  • MASHETER HC. Behcet's syndrome complicated by intracranial thrombophlebitis. Proc R Soc Med. 1959 Dec;52:1039–1040. [PubMed]
  • Padayachee TS, Bingham JB, Graves MJ, Colchester AC, Cox TC. Dural sinus thrombosis. Diagnosis and follow-up by magnetic resonance angiography and imaging. Neuroradiology. 1991;33(2):165–167. [PubMed]
  • Einhäupl KM, Villringer A, Meister W, Mehraein S, Garner C, Pellkofer M, Haberl RL, Pfister HW, Schmiedek P. Heparin treatment in sinus venous thrombosis. Lancet. 1991 Sep 7;338(8767):597–600. [PubMed]
  • Dobkin BH. Computerized tomographic findings in neuro-Behcet's disease. Arch Neurol. 1980 Jan;37(1):58–59. [PubMed]
  • Herskovitz S, Lipton RB, Lantos G. Neuro-Behçet's disease: CT and clinical correlates. Neurology. 1988 Nov;38(11):1714–1720. [PubMed]
  • Litvan I, Roig C, Rovira A, Ruscalleda J. Behçet's syndrome masquerading as tumor. Neuroradiology. 1987;29(1):103–103. [PubMed]
  • Kuroiwa Y, Tohgi H, Kanayama H, Fujimori M, Aoki H. Neuro-Behçet's disease with alternating hemiparesis. Neuroradiology. 1986;28(3):284–284. [PubMed]
  • Vidaller A, Carratalà J, Moreno R, Arbizu T, Rubio F. Magnetic resonance imaging in neuro-Behçet's disease. Br J Rheumatol. 1988 Feb;27(1):79–80. [PubMed]
  • Al Kawi MZ, Bohlega S, Banna M. MRI findings in neuro-Behçet's disease. Neurology. 1991 Mar;41(3):405–408. [PubMed]
  • Banna M, el-Ramahl K. Neurologic involvement in Behçet disease: imaging findings in 16 patients. AJNR Am J Neuroradiol. 1991 Jul-Aug;12(4):791–796. [PubMed]
  • Iseki E, Iwabuchi K, Yagishita S, Amano N, Matsushita M. Two necropsy cases of chronic encephalomyelitis: variants of Neuro-Behçet's syndrome? J Neurol Neurosurg Psychiatry. 1988 Aug;51(8):1084–1087. [PMC free article] [PubMed]
  • McAbee GN, Barasch ES. Resolving MRI lesions in lupus erythematosus selectively involving the brainstem. Pediatr Neurol. 1990 May-Jun;6(3):186–189. [PubMed]
  • Suzuki K, Hara M, Nakajima S, Hirose T, Kitani A, Norioka K, Harigai M, Kawakami M, Tabata H, Kawagoe M, et al. [Analysis of systemic lupus erythematosus (SLE) involving the central nervous system by magnetic resonance imaging (MRI)]. Ryumachi. 1989 Apr;29(2):88–96. [PubMed]
  • Paty DW, Oger JJ, Kastrukoff LF, Hashimoto SA, Hooge JP, Eisen AA, Eisen KA, Purves SJ, Low MD, Brandejs V, et al. MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT. Neurology. 1988 Feb;38(2):180–185. [PubMed]
  • Stewart JM, Houser OW, Baker HL, Jr, O'Brien PC, Rodriguez M. Magnetic resonance imaging and clinical relationships in multiple sclerosis. Mayo Clin Proc. 1987 Mar;62(3):174–184. [PubMed]
  • Pamir MN, Kansu T, Erbengi A, Zileli T. Papilledema in Behçet's syndrome. Arch Neurol. 1981 Oct;38(10):643–645. [PubMed]

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