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Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
J Neurol Neurosurg Psychiatry. 1991 December; 54(12): 1061–1062.
PMCID: PMC1014678

Acute treatment of myasthenia gravis with intranasal neostigmine: clinical and electromyographic evaluation.


The effectiveness of intranasal neostigmine (9.3-13.8 mg) was tested in 20 subjects with myasthenia gravis, classified as Osserman grades 2A and 2B. In all cases the drug produced significant clinical and electromyographic improvement. No side effects were reported during the treatment.

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Selected References

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  • Dooley JM, Goulden KJ, Gatien JG, Gibson EJ, Brown BS. Topical therapy for oropharyngeal symptoms of myasthenia gravis. Ann Neurol. 1986 Feb;19(2):192–194. [PubMed]
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  • Mantegazza R, Antozzi C, Peluchetti D, Sghirlanzoni A, Cornelio F. Azathioprine as a single drug or in combination with steroids in the treatment of myasthenia gravis. J Neurol. 1988 Nov;235(8):449–453. [PubMed]
  • Ozdemir C, Young RR. Electrical testing in myasthenia gravis. Ann N Y Acad Sci. 1971 Sep 15;183:287–302. [PubMed]
  • Slomić A, Rosenfalck A, Buchthal F. Electrical and mechanical responses of normal and myasthenic muscle. Brain Res. 1968 Aug 5;10(1):1–78. [PubMed]

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