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J Med Genet. 1978 August; 15(4): 254–259.
PMCID: PMC1013693

Genetic study of narcoleptic syndrome.


In this family study of the narcoleptic syndrome, 52% of the probands had an affected first degree relative, 41.9% of the sibs of those probands with an affected parent were similarly affected, 33.3% of the parents of 2 affected sibs and 41.2% of the children (after a correction for age) had narcolepsy, cataplexy, or both.

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Selected References

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  • DALY DD, YOSS RE. A family with narcolepsy. Proc Staff Meet Mayo Clin. 1959 Jun 10;34:313–319. [PubMed]
  • Gelardi JM, Brown JW. Hereditary cataplexy. J Neurol Neurosurg Psychiatry. 1967 Oct;30(5):455–457. [PMC free article] [PubMed]
  • Guilleminault C, Carskadon M, Dement WC. On the treatment of rapid eye movement narcolepsy. Arch Neurol. 1974 Jan;30(1):90–93. [PubMed]
  • IMLAH NW. Narcolepsy in identical twins. J Neurol Neurosurg Psychiatry. 1961 May;24:158–160. [PMC free article] [PubMed]
  • Kessler S, Guilleminault C, Dement W. A family study of 50 REM narcoleptics. Acta Neurol Scand. 1974;50(4):503–512. [PubMed]
  • NEVSIMAL O, ROTH B. Prïpad rodinného výskytu narkolepsie. Cesk Neurol. 1958 Jan;21(1):54–58. [PubMed]
  • RECHTSCHAFFEN A, WOLPERT EA, DEMENT WC, MITCHELL SA, FISHER C. NOCTURNAL SLEEP OF NARCOLEPTICS. Electroencephalogr Clin Neurophysiol. 1963 Aug;15:599–609. [PubMed]
  • YOSS RE, DALY DD. Criteria for the diagnosis of the narcoleptic syndrome. Proc Staff Meet Mayo Clin. 1957 Jun 12;32(12):320–328. [PubMed]
  • YOSS RE, DALY DD. Hereditary aspects of narcolepsy. Trans Am Neurol Assoc. 1960;85:239–240. [PubMed]

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