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J Med Genet. 1973 June; 10(2): 158–160.
PMCID: PMC1013007

A Family with Heritable Electrocardiographic QT-prolongation

Abstract

A report is presented concerning a family with heritable electrocardiographic QT-prolongation attacks of syncope and possible sudden death. In 23 family members investigated, nine living cases were found to have the anomaly. Of these nine patients at least two had had syncopes in early childhood. Hearing loss was found in three of the nine patients, but in one of them this could have been due to noise trauma and in another hearing loss was unilateral. The inheritance follows an autosomal dominant pattern. As far as we know this is the first report of this disease from The Netherlands.

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Selected References

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  • FRASER GR, FROGGATT P, JAMES TN. CONGENITAL DEAFNESS ASSOCIATED WITH ELECTROCARDIOGRAPHIC ABNORMALITIES, FAINTING ATTACKS AND SUDDEN DEATH. A RECESSIVE SYNDROME. Q J Med. 1964 Jul;33:361–385. [PubMed]
  • Garza LA, Vick RL, Nora JJ, McNamara DG. Heritable Q-T prolongation without deafness. Circulation. 1970 Jan;41(1):39–48. [PubMed]
  • JERVELL A, LANGE-NIELSEN F. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death. Am Heart J. 1957 Jul;54(1):59–68. [PubMed]
  • ROMANO C. CONGENITAL CARDIAC ARRHYTHMIA. Lancet. 1965 Mar 20;1(7386):658–659. [PubMed]

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