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J Med Genet. 1979 February; 16(1): 17–20.
PMCID: PMC1012774

Familial caudal regression anomalad and maternal diabetes.


A family is reported which a diabetic woman gave birth to two children with the caudal regression anomalad (CRA). There were no obvious genetic factors. This is the first reported familial case of CRA with maternal diabetes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ashcraft KW, Holder TM, Harris DJ. Familial presacral teratomas. Birth Defects Orig Artic Ser. 1975;11(5):143–146. [PubMed]
  • Finer NN, Bowen P, Dunbar LG. Caudal regression anomalad (sacral agenesis) in siblings. Clin Genet. 1978 Apr;13(4):353–358. [PubMed]
  • Passarge E, Lenz W. Syndrome of caudal regression in infants of diabetic mothers: observations of further cases. Pediatrics. 1966 Apr;37(4):672–675. [PubMed]
  • Robert J, Pernod J, Bonnet R. L'agénésie sacro-coccygienne familiale. A propos de 6 cas dans deux familles. J Genet Hum. 1974 Mar;22(1):45–60. [PubMed]
  • Say B, Coldwell JG. Hereditary defect of the sacrum. Humangenetik. 1975;27(3):231–234. [PubMed]

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