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Br J Ind Med. 1993 August; 50(8): 704–709.
PMCID: PMC1012173

Mortality study of ethylene oxide workers in chemical manufacturing: a 10 year update.


Men assigned to units producing ethylene oxide by the chlorohydrin or direct oxidation processes and to other departments using ethylene oxide in two chemical plants were followed up for mortality from 1940 to 1988 (n = 1896). Based on findings from a previous study of these workers to the end of 1978, which identified confounding exposures, workers assigned to one unit with low ethylene oxide exposure potential were excluded (n = 278). Average duration of exposure was over five years and average follow up was 27 years, with all subjects at least 10 years from first exposure. The data did not support associations of ethylene oxide with all cancer types combined, leukaemia, non-Hodgkin's lymphoma, or brain, pancreatic, or stomach cancers. There were also no duration-response trends. The standardised mortality ratio (SMR) for total cancer was 86 (95% confidence interval 71-104) and did not increase for those hired the earliest and with long duration assignments. The results of this 10 year update and those of other recent studies of ethylene oxide workers do not confirm findings from animal studies and are not consistent with the earliest results reported among ethylene oxide workers.

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Selected References

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  • Snellings WM, Weil CS, Maronpot RR. A two-year inhalation study of the carcinogenic potential of ethylene oxide in Fischer 344 rats. Toxicol Appl Pharmacol. 1984 Aug;75(1):105–117. [PubMed]
  • Lynch DW, Lewis TR, Moorman WJ, Burg JR, Groth DH, Khan A, Ackerman LJ, Cockrell BY. Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats. Toxicol Appl Pharmacol. 1984 Oct;76(1):69–84. [PubMed]
  • Garman RH, Snellings WM, Maronpot RR. Brain tumors in F344 rats associated with chronic inhalation exposure to ethylene oxide. Neurotoxicology. 1985 Spring;6(1):117–137. [PubMed]
  • Hogstedt C, Malmqvist N, Wadman B. Leukemia in workers exposed to ethylene oxide. JAMA. 1979 Mar 16;241(11):1132–1133. [PubMed]
  • Hogstedt C, Aringer L, Gustavsson A. Epidemiologic support for ethylene oxide as a cancer-causing agent. JAMA. 1986 Mar 28;255(12):1575–1578. [PubMed]
  • Hogstedt LC. Epidemiological studies on ethylene oxide and cancer: an updating. IARC Sci Publ. 1988;(89):265–270. [PubMed]
  • Gardner MJ, Coggon D, Pannett B, Harris EC. Workers exposed to ethylene oxide: a follow up study. Br J Ind Med. 1989 Dec;46(12):860–865. [PMC free article] [PubMed]
  • Kiesselbach N, Ulm K, Lange HJ, Korallus U. A multicentre mortality study of workers exposed to ethylene oxide. Br J Ind Med. 1990 Mar;47(3):182–188. [PMC free article] [PubMed]
  • Hagmar L, Welinder H, Lindén K, Attewell R, Osterman-Golkar S, Törnqvist M. An epidemiological study of cancer risk among workers exposed to ethylene oxide using hemoglobin adducts to validate environmental exposure assessments. Int Arch Occup Environ Health. 1991;63(4):271–277. [PubMed]
  • Morgan RW, Claxton KW, Divine BJ, Kaplan SD, Harris VB. Mortality among ethylene oxide workers. J Occup Med. 1981 Nov;23(11):767–770. [PubMed]
  • Greenberg HL, Ott MG, Shore RE. Men assigned to ethylene oxide production or other ethylene oxide related chemical manufacturing: a mortality study. Br J Ind Med. 1990 Apr;47(4):221–230. [PMC free article] [PubMed]
  • Steenland K, Stayner L, Greife A, Halperin W, Hayes R, Hornung R, Nowlin S. Mortality among workers exposed to ethylene oxide. N Engl J Med. 1991 May 16;324(20):1402–1407. [PubMed]
  • Benson LO, Teta MJ. Mortality due to pancreatic and lymphopoietic cancers in chlorohydrin production workers. Br J Ind Med. 1993 Aug;50(8):710–716. [PMC free article] [PubMed]
  • Schulte PA, Boeniger M, Walker JT, Schober SE, Pereira MA, Gulati DK, Wojciechowski JP, Garza A, Froelich R, Strauss G, et al. Biologic markers in hospital workers exposed to low levels of ethylene oxide. Mutat Res. 1992 Apr;278(4):237–251. [PubMed]

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