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Genitourin Med. 1985 June; 61(3): 165–167.
PMCID: PMC1011795

Augmentin compared with amoxycillin in treating uncomplicated gonorrhoea.


We studied 220 patients (138 men and 82 women) with uncomplicated gonorrhoea who were entered into a randomised double blind trial and treated with either Augmentin (amoxycillin 3 g and potassium clavulanate 125 mg) or amoxycillin 3 g, with probenecid 1 g by mouth in all cases. Seven (6.5%) of 108 patients treated with Augmentin were still culture positive after treatment, compared with 15 (13.4%) of 112 of those treated with amoxycillin. Penicillinase (beta lactamase) producing strains of Neisseria gonorrhoeae (PPNG) were found in 23 (10.5%) patients, of whom 10 were treated with Augmentin and 13 with amoxycillin. Treatment failed in all 13 patients who received amoxycillin. Augmentin was shown to be an effective treatment for gonorrhoea caused by PPNG strains.

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Selected References

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  • Thin RN, Barlow D, Eykyn S, Phillips I. Imported penicillinase producing Neisseria gonorrhoeae becomes endemic in London. Br J Vener Dis. 1983 Dec;59(6):364–368. [PMC free article] [PubMed]
  • McCutchan JA, Adler MW, Berrie JR. Penicillinase-producing Neisseria gonorrhoeae in Great Britain, 1977-81: alarming increase in incidence and recent development of endemic transmission. Br Med J (Clin Res Ed) 1982 Jul 31;285(6338):337–340. [PMC free article] [PubMed]
  • Ashford WA, Potts DW, Adams HJ, English JC, Johnson SR, Biddle JW, Thornsberry C, Jaffe HW. Spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae. Lancet. 1981 Nov 7;2(8254):1035–1037. [PubMed]
  • Easmon CS, Ison CA, Bellinger CM, Harris JW. Emergence of resistance after spectinomycin treatment for gonorrhoea due to beta-lactamase producing strain of Neisseria gonorrhoeae. Br Med J (Clin Res Ed) 1982 May 29;284(6329):1604–1605. [PMC free article] [PubMed]
  • Lim VK, Bakar R, Hussin Z. Single dose oral amoxycillin and clavulanic acid in the treatment of gonococcal urethritis in males. Med J Malaysia. 1982 Sep;37(3):235–238. [PubMed]

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