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Br J Ind Med. 1975 November; 32(4): 329–333.
PMCID: PMC1008084

Tetramethyl lead absorption: a report of human exposure to a high level of tetramethyl lead.


Accidental human exposure to a high level of tetramethyl lead is described. Tetramethyl lead is blended with petrol as an antiknock agent, and it has similar physical properties to tetraethyl lead. The patient had high levels of lead in urine, averaging 4-75 mumol (983 mug) daily for the first four days after exposure and he continued to have raised levels of urinary lead for six months. He had no symptoms or physical signs of lead poisoning and comparisons are made between this case and previously reported cases of poisoning by tetraethyl lead. In the cases of tetraethyl lead poisoning all the patients had symptoms, some severe, yet in no instance did the urinary lead levels approach those described in this patient. The effects of chelation therapy with calcium disodium versenate are discussed and the results are similar to those found in tetraethyl lead poisoning. Blood lead levels of up to 3-91 mumol/l (81 mug/100 g) occurred but these levels were not raised commensurate with the urinary lead output. The levels of deltaaminolaevulinic acid (ALA) in the urine were not significantly raised and this report shows that the urinary lead levels give a better guide to the degree of absorption of tetramethyl lead compared with the blood lead or urinary ALA levels. The report illustrates that tetramethyl lead is less toxic to man than tetraethyl lead.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Beattie AD, Moore MR, Goldberg A. Tetraethyl-lead poisoning. Lancet. 1972 Jul 1;2(7766):12–15. [PubMed]
  • BOYD PR, HENDERSON IN, WALKER G. The treatment of tetraethyl lead poisoning. Lancet. 1957 Jan 26;272(6961):181–185. [PubMed]
  • Browett EV, Moss R. Manual and semi-automatic methods for the determination of the lead content of urine. Analyst. 1965 Dec;90(77):715–726. [PubMed]
  • CASSELLS DAK, DODDS EC. Tetraethyl lead poisoning. Br Med J. 1946 Nov 9;2(4479):681–685. [PMC free article] [PubMed]
  • CREMER JE. Biochemical studies on the toxicity of tetraethyl lead and other organo-lead compounds. Br J Ind Med. 1959 Jul;16:191–199. [PMC free article] [PubMed]
  • CREMER JE, CALLAWAY S. Further studies on the toxicity of some tetra and trialkyl lead compounds. Br J Ind Med. 1961 Oct;18:277–282. [PMC free article] [PubMed]
  • Davis JR, Andelman SL. Urinary delta-aminolevulinic acid (ALA) levels in lead poisoning. I. A modified method for the rapid determination of urinary delta-aminolevulinic acid using disposable ion-exchange chromatography columns. Arch Environ Health. 1967 Jul;15(1):53–59. [PubMed]
  • DAVIS RK, HORTON AW, LARSON EE, STEMMER KL. Inhalation of tetramethyllead and tetraethyllead. A comparison of the effects in rats and dogs. Arch Environ Health. 1963 Apr;6:473–479. [PubMed]
  • KEHOE RA. The Harben Lectures, 1960: The metabolism of lead in man in health and disease. 3. Present hygienic problems relating to the absorption of lead. J R Inst Public Health. 1961 Aug;24:177–203. [PubMed]
  • SPRINGMAN F, BINGHAM E, STEMMER KL. The acute effects of lead alkyls. Oral administration of tetramethyllead, tetraethyllead, trimethyllead chloride, triethyllead chloride, and diethyllead dichloride to rats. Arch Environ Health. 1963 Apr;6:469–472. [PubMed]
  • Thompson JA. Balance between intake and output of lead in normal individuals. Br J Ind Med. 1971 Apr;28(2):189–194. [PMC free article] [PubMed]
  • WALKER G, BOYD PR. Tetraethyl lead poisoning; report of a non-fatal case. Lancet. 1952 Sep 6;2(6732):467–469. [PubMed]

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