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Ann Rheum Dis. 1994 May; 53(5): 327–330.
PMCID: PMC1005332

Cerebellum and brainstem vasculopathy in systemic lupus erythematosus: two clinico-pathological cases.


The case histories are reported of two patients with systemic lupus erythematosus (SLE) who developed fatal neurological involvement, each presenting with cerebellar and brainstem signs. Neuro-pathological changes were confined to the cerebellum and brainstem, with clear evidence of a small vessel vasculopathy. The predominant histological abnormalities were multiple perivascular haemorrhages in one case and classical vasculitic changes in the other.

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Selected References

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  • Adelman DC, Saltiel E, Klinenberg JR. The neuropsychiatric manifestations of systemic lupus erythematosus: an overview. Semin Arthritis Rheum. 1986 Feb;15(3):185–199. [PubMed]
  • Johnson RT, Richardson EP. The neurological manifestations of systemic lupus erythematosus. Medicine (Baltimore) 1968 Jul;47(4):337–369. [PubMed]
  • Sergent JS, Lockshin MD, Klempner MS, Lipsky BA. Central nervous system disease in systemic lupus erythematosus. Therapy and prognosis. Am J Med. 1975 May;58(5):644–654. [PubMed]
  • Feinglass EJ, Arnett FC, Dorsch CA, Zizic TM, Stevens MB. Neuropsychiatric manifestations of systemic lupus erythematosus: diagnosis, clinical spectrum, and relationship to other features of the disease. Medicine (Baltimore) 1976 Jul;55(4):323–339. [PubMed]
  • Ellis SG, Verity MA. Central nervous system involvement in systemic lupus erythematosus: a review of neuropathologic findings in 57 cases, 1955--1977. Semin Arthritis Rheum. 1979 Feb;8(3):212–221. [PubMed]
  • Tuchman AJ, Daras M, David S. Cerebellar ataxia in systemic lupus erythematosus. N Y State J Med. 1983 Jun;83(7):983–984. [PubMed]
  • Singh RR, Prasad K, Kumar A, Misra A, Padmakumar K, Malaviya AN. Cerebellar ataxia in systemic lupus erythematosus: three case reports. Ann Rheum Dis. 1988 Nov;47(11):954–956. [PMC free article] [PubMed]
  • Sibley JT, Olszynski WP, Decoteau WE, Sundaram MB. The incidence and prognosis of central nervous system disease in systemic lupus erythematosus. J Rheumatol. 1992 Jan;19(1):47–52. [PubMed]
  • Devinsky O, Petito CK, Alonso DR. Clinical and neuropathological findings in systemic lupus erythematosus: the role of vasculitis, heart emboli, and thrombotic thrombocytopenic purpura. Ann Neurol. 1988 Apr;23(4):380–384. [PubMed]
  • Hanly JG, Walsh NM, Sangalang V. Brain pathology in systemic lupus erythematosus. J Rheumatol. 1992 May;19(5):732–741. [PubMed]
  • Bunning RD, Laureno R, Barth WF. Florid central nervous system vasculitis in a fatal case of systemic lupus erythematosus. J Rheumatol. 1982 Sep-Oct;9(5):735–738. [PubMed]
  • Ellison D, Gatter K, Heryet A, Esiri M. Intramural platelet deposition in cerebral vasculopathy of systemic lupus erythematosus. J Clin Pathol. 1993 Jan;46(1):37–40. [PMC free article] [PubMed]
  • Sibbitt WL, Jr, Sibbitt RR, Griffey RH, Eckel C, Bankhurst AD. Magnetic resonance and computed tomographic imaging in the evaluation of acute neuropsychiatric disease in systemic lupus erythematosus. Ann Rheum Dis. 1989 Dec;48(12):1014–1022. [PMC free article] [PubMed]

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