Search tips
Search criteria 


Logo of westjmedLink to Publisher's site
West J Med. 1990 July; 153(1): 62–64.
PMCID: PMC1002468

Clozapine—A New and Different Neuroleptic


These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from a transcription, it has been edited by Homer A. Boushey, MD, Professor of Medicine, and Nathan M. Bass, MD, PhD, Associate Professor of Medicine, under the direction of Lloyd H. Smith, Jr, MD, Professor of Medicine and Associate Dean in the School of Medicine.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (750K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Davis JM, Schaffer CB, Killian GA, Kinard C, Chan C. Important issues in the drug treatment of schizophrenia. Schizophr Bull. 1980;6(1):70–87. [PubMed]
  • Kane J, Honigfeld G, Singer J, Meltzer H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry. 1988 Sep;45(9):789–796. [PubMed]
  • Claghorn J, Honigfeld G, Abuzzahab FS, Sr, Wang R, Steinbook R, Tuason V, Klerman G. The risks and benefits of clozapine versus chlorpromazine. J Clin Psychopharmacol. 1987 Dec;7(6):377–384. [PubMed]
  • Gerlach J, Koppelhus P, Helweg E, Monrad A. Clozapine and haloperidol in a single-blind cross-over trial: therapeutic and biochemical aspects in the treatment of schizophrenia. Acta Psychiatr Scand. 1974;50(4):410–424. [PubMed]
  • Shopsin B, Klein H, Aaronsom M, Collora M. Clozapine, chlorpromazine, and placebo in newly hospitalized, acutely schizophrenic patients: a controlled, double-blind comparison. Arch Gen Psychiatry. 1979 Jun;36(6):657–664. [PubMed]
  • Small JG, Milstein V, Marhenke JD, Hall DD, Kellams JJ. Treatment outcome with clozapine in tardive dyskinesia, neuroleptic sensitivity, and treatment-resistant psychosis. J Clin Psychiatry. 1987 Jul;48(7):263–267. [PubMed]
  • Matz R, Rick W, Thompson H, Gershon S. Clozapine--a potential antipsychotic agent without extrapyramidal manifestations. Curr Ther Res Clin Exp. 1974 Jul;16(7):687–695. [PubMed]
  • Kane JM, Woerner M, Borenstein M, Wegner J, Lieberman J. Integrating incidence and prevalence of tardive dyskinesia. Psychopharmacol Bull. 1986;22(1):254–258. [PubMed]
  • Jenner P, Rupniak NM, Marsden CD. Differential alteration of striatal D-1 and D-2 receptors induced by the long-term administration of haloperidol, sulpiride or clozapine to rats. Psychopharmacology Suppl. 1985;2:174–181. [PubMed]
  • Seeger TF, Thal L, Gardner EL. Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol. Psychopharmacology (Berl) 1982;76(2):182–187. [PubMed]
  • Andén NE, Stock G. Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system. J Pharm Pharmacol. 1973 Apr;25(4):346–348. [PubMed]
  • Kane JM, Cooper TB, Sachar EJ, Halpern FS, Bailine S. Clozapine: plasma levels and prolactin response. Psychopharmacology (Berl) 1981;73(2):184–187. [PubMed]
  • Meltzer HY, Goode DJ, Schyve PM, Young M, Fang VS. Effect of clozapine on human serum prolactin levels. Am J Psychiatry. 1979 Dec;136(12):1550–1555. [PubMed]
  • Peroutka SJ, Synder SH. Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry. 1980 Dec;137(12):1518–1522. [PubMed]
  • Richelson E. Neuroleptic affinities for human brain receptors and their use in predicting adverse effects. J Clin Psychiatry. 1984 Aug;45(8):331–336. [PubMed]
  • Griffith RW, Saameli K. Letter: Clozapine and agranulocytosis. Lancet. 1975 Oct 4;2(7936):657–657. [PubMed]
  • Lieberman JA, Johns CA, Kane JM, Rai K, Pisciotta AV, Saltz BL, Howard A. Clozapine-induced agranulocytosis: non-cross-reactivity with other psychotropic drugs. J Clin Psychiatry. 1988 Jul;49(7):271–277. [PubMed]

Articles from The Western Journal of Medicine are provided here courtesy of BMJ Publishing Group