Search tips
Search criteria 


Logo of annrheumdAnnals of the Rheumatic DiseasesVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Ann Rheum Dis. 1986 September; 45(9): 726–731.
PMCID: PMC1001977

Cyclosporin treatment for rheumatoid arthritis: a placebo controlled, double blind, multicentre study.


The efficacy and safety of cyclosporin for patients with rheumatoid arthritis (RA) were assessed in a six month double blind, placebo controlled, multicentre study. The initial dosage of the drug was 10 mg/kg daily for two months. There were many discontinuations in both the cyclosporin group (eight out of 17) and the placebo group (six out of 19). Of the patients who completed the six months of therapy, those who had received cyclosporin showed a significant improvement in the number of swollen joints, the Ritchie articular index, and pain at active movement and at rest, compared not only with their condition at the start of the study, but also with the end results of the placebo group. Major adverse reactions to the drug were gastrointestinal disturbances and nephrotoxicity, which were probably due to the relatively high dosages of cyclosporin given in combination with non-steroidal anti-inflammatory drugs.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (706K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • HAMILTON EB, SCOTT JT. Hydroxychloroquine sulfate ("plaguenil") in treatment of rheumatoid arthritis. Arthritis Rheum. 1962 Oct;5:502–512. [PubMed]
  • Sigler JW, Bluhm GB, Duncan H, Sharp JT, Ensign DC, McCrum WR. Gold salts in the treatment of rheumatoid arthritis. A double-blind study. Ann Intern Med. 1974 Jan;80(1):21–26. [PubMed]
  • Berry H, Liyanage S, Durance R, Barnes CG, Berger L. Trial comparing azathioprine and penicillamine in treatment of rheumatoid arthritis [proceedings]. Ann Rheum Dis. 1976 Dec;35(6):542–543. [PMC free article] [PubMed]
  • Weinblatt ME, Coblyn JS, Fox DA, Fraser PA, Holdsworth DE, Glass DN, Trentham DE. Efficacy of low-dose methotrexate in rheumatoid arthritis. N Engl J Med. 1985 Mar 28;312(13):818–822. [PubMed]
  • Klippel JH, Decker JL. Methotrexate in rheumatoid arthritis. N Engl J Med. 1985 Mar 28;312(13):853–854. [PubMed]
  • Hess AD, Tutschka PJ, Pu Z, Santos GW. Effect of cyclosporin A on human lymphocyte responses in vitro. IV. Production of T cell stimulatory growth factors and development of responsiveness to these growth factors in CsA-treated primary MLR cultures. J Immunol. 1982 Jan;128(1):360–367. [PubMed]
  • Borel JF. Cyclosporin-A--present experimental status. Transplant Proc. 1981 Mar;13(1 Pt 1):344–348. [PubMed]
  • Henderson B, Staines NA, Burrai I, Cox JH. The anti-arthritic and immunosuppressive effects of cyclosporine on arthritis induced in the rat by type II collagen. Clin Exp Immunol. 1984 Jul;57(1):51–56. [PubMed]
  • Nussenblatt RB, Palestine AG, Chan CC, Mochizuki M, Yancey K. Effectiveness of cyclosporin therapy for Behçet's disease. Arthritis Rheum. 1985 Jun;28(6):671–679. [PubMed]
  • Stiller CR, Dupré J, Gent M, Jenner MR, Keown PA, Laupacis A, Martell R, Rodger NW, von Graffenried B, Wolfe BM. Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science. 1984 Mar 30;223(4643):1362–1367. [PubMed]
  • Donatsch P, Abisch E, Homberger M, Traber R, Trapp M, Voges R. A radioimmunoassay to measure cyclosporin A in plasma and serum samples. J Immunoassay. 1981;2(1):19–32. [PubMed]
  • Iannuzzi L, Dawson N, Zein N, Kushner I. Does drug therapy slow radiographic deterioration in rheumatoid arthritis? N Engl J Med. 1983 Oct 27;309(17):1023–1028. [PubMed]
  • Chapman JR, Griffiths D, Harding NG, Morris PJ. Reversibility of cyclosporin nephrotoxicity after three months' treatment. Lancet. 1985 Jan 19;1(8421):128–130. [PubMed]
  • Kimberly RP, Bowden RE, Keiser HR, Plotz PH. Reduction of renal function by newer nonsteroidal anti-inflammatory drugs. Am J Med. 1978 May;64(5):804–807. [PubMed]
  • Breedveld FC, Valentijn RM, Westedt ML, Weening JJ. Rapidly progressive glomerulonephritis with glomerular crescent formation in rheumatoid arthritis. Clin Rheumatol. 1985 Sep;4(3):353–359. [PubMed]
  • Sun DC, Roth SH, Mitchell CS, Englund DW. Upper gastrointestinal disease in rheumatoid arthritis. Am J Dig Dis. 1974 May;19(5):405–410. [PubMed]
  • Ciabattoni G, Cinotti GA, Pierucci A, Simonetti BM, Manzi M, Pugliese F, Barsotti P, Pecci G, Taggi F, Patrono C. Effects of sulindac and ibuprofen in patients with chronic glomerular disease. Evidence for the dependence of renal function on prostacyclin. N Engl J Med. 1984 Feb 2;310(5):279–283. [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group