Search tips
Search criteria 


Logo of annrheumdAnnals of the Rheumatic DiseasesVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Ann Rheum Dis. 1980 October; 39(5): 417–423.
PMCID: PMC1000578

Renal impairment and gout.


A study of renal function of 51 patients with gout and an equal number of normouricaemic controls revealed significant differences. A relative impairment of the glomerular filtration rate and urine concentrating ability in the gouty subjects could not be wholly explained on the basis of aging or hypertension. Renal dysfunction was generally mild and was not associated with specific clinical characteristics higher levels of uric acid excretion, or hypertriglyceridaemia. Gout patients excreted urine with a significantly lower pH. This was associated with a relatively high excretion of titratable acid and a deficit of ammonium excretion, which was accentuated by ingestion of an acid load. Urate clearance was significantly reduced in gout, even when expressed as a fraction of the glomerular filtration rate.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (856K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Currie WJ. The gout patient in general practice. Rheumatol Rehabil. 1978 Nov;17(4):205–217. [PubMed]
  • TALBOTT JH, TERPLAN KL. The kidney in gout. Medicine (Baltimore) 1960 Dec;39:405–467. [PubMed]
  • Steele TH. Asymptomatic hyperuricemia: pathogenic or innocent bystander? Arch Intern Med. 1979 Jan;139(1):24–25. [PubMed]
  • Berger L, Yü TF. Renal function in gout. IV. An analysis of 524 gouty subjects including long-term follow-up studies. Am J Med. 1975 Nov;59(5):605–613. [PubMed]
  • Fessel WJ, Siegelaub AB, Johnson ES. Correlates and consequences of asymptomatic hyperuricemia. Arch Intern Med. 1973 Jul;132(1):44–54. [PubMed]
  • Klinenberg JR, Gonick HC, Dornfeld L. Renal function abnormalities in patients with asymptomatic hyperuricemia. Arthritis Rheum. 1975 Nov-Dec;18(6 Suppl):725–730. [PubMed]
  • Garnett ES, Parsons V, Veall N. Measurement of glomerular filtration-rate in man using a 51Cr-edetic-acid complex. Lancet. 1967 Apr 15;1(7494):818–819. [PubMed]
  • SEARCY RL, BERGQUIST LM. A new color reaction for the quantitation of serum cholesterol. Clin Chim Acta. 1960 Mar;5:192–199. [PubMed]
  • WRONG O, DAVIES HE. The excretion of acid in renal disease. Q J Med. 1959 Apr;28(110):259–313. [PubMed]
  • Grahame R, Scott JT. Clinical survey of 354 patients with gout. Ann Rheum Dis. 1970 Sep;29(5):461–468. [PMC free article] [PubMed]
  • Warren SE, Ebert E, Swerdlin AH, Steinberg SM, Stone R. Clonidine and propranolol paradoxical hypertension. Arch Intern Med. 1979 Feb;139(2):253–253. [PubMed]
  • Barlow KA, Beilin LJ. Renal disease in primary gout. Q J Med. 1968 Jan;37(145):79–96. [PubMed]
  • DUNCAN H, DIXON AS. Gout, familial hypericaemia, and renal disease. Q J Med. 1960 Jan;29:127–135. [PubMed]
  • GUTMAN AB, YU TF. Renal function in gout; with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout. Am J Med. 1957 Oct;23(4):600–622. [PubMed]
  • Gibson T, Grahame R. Gout and hyperlipidaemia. Ann Rheum Dis. 1974 Jul;33(4):298–303. [PMC free article] [PubMed]
  • Klatsky AL, Friedman GD, Siegelaub AB, Gérard MJ. Alcohol consumption and blood pressure Kaiser-Permanente Multiphasic Health Examination data. N Engl J Med. 1977 May 26;296(21):1194–1200. [PubMed]
  • Ramsay LE. Hyperuricaemia in hypertension: role of alcohol. Br Med J. 1979 Mar 10;1(6164):653–654. [PMC free article] [PubMed]
  • GUTMAN AB, YUE TF. URINARY AMMONIUM EXCRETION IN PRIMARY GOUT. J Clin Invest. 1965 Sep;44:1474–1481. [PMC free article] [PubMed]
  • Falls WF., Jr Comparison of urinary acidification and ammonium excretion in normal and gouty subjects. Metabolism. 1972 May;21(5):433–445. [PubMed]
  • PAKPOY RK. URINARY PH IN GOUT. Australas Ann Med. 1965 Feb;14:35–39. [PubMed]
  • Gutman AB, Yü TF, Berger L. Renal function in gout. 3. Estimation of tubular secretion and reabsorption of uric acid by use of pyrazinamide (pyrazinoic acid). Am J Med. 1969 Oct;47(4):575–592. [PubMed]
  • Nugent CA. Renal urate excretion in gout studied by feeding ribonucleic acid. Arthritis Rheum. 1965 Oct;8(5):671–685. [PubMed]
  • Simkin PA. Urate excretion in normal and gouty men. Adv Exp Med Biol. 1977;76B:41–45. [PubMed]
  • Snaith ML, Scott JT. Uric acid clearance in patients with gout and normal subjects. Ann Rheum Dis. 1971 May;30(3):285–289. [PMC free article] [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group