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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
J Am Geriatr Soc. Author manuscript; available in PMC 2008 June 3.
Published in final edited form as:
J Am Geriatr Soc. 2007 May; 55(5): 780–791.
doi: 10.1111/j.1532-5415.2007.01156.x

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A unifying conceptual model demonstrates that shared risk factors may lead to geriatric syndromes, which may in turn lead to frailty, with feedback mechanisms enhancing the presence of shared risk factors and geriatric syndromes. Such self-sustaining pathways may result in poor outcomes involving disability-dependence, nursing home placement, and ultimately death, thus holding important implications for elucidating pathophysiologic mechanisms and designing effective intervention strategies.

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