Hypertrophic cardiomyopathy in infants of poorly-controlled diabetic mothers.]]>Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ ]]>
Arch Dis Child. 1981 April; 56(4): 258–263.
PMCID: PMC1627227

Hypertrophic cardiomyopathy in infants of poorly-controlled diabetic mothers.

Abstract

Twelve newborn infants of poorly-controlled diabetic mothers were transferred from outlying maternity hospitals for neonatal intensive care. Respiratory distress and cardiomegaly were the presenting signs. Ten infants were large for dates (macrosomic) and had echocardiographic evidence of myocardial hypertrophy, reduced ejection time, and systolic anterior movement of the mitral valve (in 6 infants). These findings are similar to those of adults with idiopathic hypertrophic subaortic stenosis. Two infants died. In survivors the myocardial hypertrophy persisted for at least 2 weeks but the evidence of functional subaortic stenosis had disappeared by 4-7 days. The 2 infants who were appropriately grown had cardiomegaly as a result of ventricular dilatation. This was associated with hypoglycaemia and acidosis, and disappeared when these metabolic disturbances were corrected.

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Selected References

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  • Gutgesell HP, Mullins CE, Gillette PC, Speer M, Rudolph AJ, McNamara DG. Transient hypertrophic subaortic stenosis in infants of diabetic mothers. J Pediatr. 1976 Jul;89(1):120–125. [PubMed]
  • WHITE P. PREGNANCY AND DIABETES, MEDICAL ASPECTS. Med Clin North Am. 1965 Jul;49:1015–1024. [PubMed]
  • Thomson AM, Billewicz WZ, Hytten FE. The assessment of fetal growth. J Obstet Gynaecol Br Commonw. 1968 Sep;75(9):903–916. [PubMed]
  • Hagan AD, Deely WJ, Sahn D, Friedman WF. Echocardiographic criteria for normal newborn infants. Circulation. 1973 Dec;48(6):1221–1226. [PubMed]
  • Solinger R, Elbl F, Minhas K. Echocardiography in the normal neonate. Circulation. 1973 Jan;47(1):108–118. [PubMed]
  • Lewis RP, Sandler H. Relationship between changes in left ventricular dimensions and the ejection fraction in man. Circulation. 1971 Oct;44(4):548–557. [PubMed]
  • Hirschfeld S, Meyer R, Schwartz DC, Korfhagen J, Kaplan S. Measurement of right and left ventricular systolic time intervals by echocardiography. Circulation. 1975 Feb;51(2):304–309. [PubMed]
  • Halliday H, Hirschfeld S, Riggs T, Liebman J, Fanaroff A. Echographic ventricular systolic time intervals in normal term and preterm neonates. Pediatrics. 1978 Sep;62(3):317–321. [PubMed]
  • SCHULZ DM, GIORDANO DA, SCHULZ DH. Weights of organs of fetuses and infants. Arch Pathol. 1962 Sep;74:244–250. [PubMed]
  • NAEYE RL. INFANTS OF DIABETIC MOTHERS: A QUANTITATIVE, MORPHOLOGIC STUDY. Pediatrics. 1965 Jun;35:980–988. [PubMed]
  • Henry WL, Clark CE, Epstein SE. Asymmetric septal hypertrophy. Echocardiographic identification of the pathognomonic anatomic abnormality of IHSS. Circulation. 1973 Feb;47(2):225–233. [PubMed]
  • Shah PM, Gramiak R, Adelman AG, Wigle ED. Role of echocardiography in diagnostic and hemodynamic assessment of hypertrophic subaortic stenosis. Circulation. 1971 Nov;44(5):891–898. [PubMed]
  • Abbasi AS, MacAlpin RN, Eber LM, Pearce ML. Echocardiographic diagnosis of idiopathic hypertrophic cardiomyopathy without outflow obstruction. Circulation. 1972 Nov;46(5):897–904. [PubMed]
  • Boughner DR, Schuld RL, Persaud JA. Hypertrophic obstructive cardiomyopathy. Assessment by echocardiographic and Doppler ultrasound techniques. Br Heart J. 1975 Sep;37(9):917–923. [PMC free article] [PubMed]
  • Shand DG, Sell CG, Oates JA. Hypertrophic obstructive cardiomyopathy in an infant--propranolol therapy for three years. N Engl J Med. 1971 Oct 7;285(15):843–844. [PubMed]
  • Barr PA, Celermajer JM, Bowdler JD, Cartmill TB. Idiopathic hypertrophic obstructive cardiomyopathy causing severe right ventricular outflow tract obstruction in infancy. Br Heart J. 1973 Nov;35(11):1109–1115. [PMC free article] [PubMed]
  • Maron BJ, Edwards JE, Henry WL, Clark CE, Bingle GJ, Epstein SE. Asymmetric septal hypertrophy (ASH) in infancy. Circulation. 1974 Oct;50(4):809–820. [PubMed]
  • Reid MM, Reilly BJ, Murdock AI, Swyer PR. Cardiomegaly in association with neonatal hypoglycaemia. Acta Paediatr Scand. 1971 May;60(3):295–298. [PubMed]
  • Amatayakul O, Cumming GR, Haworth JC. Association of hypoglycaemia with cardiac enlargement and heart failure in newborn infants. Arch Dis Child. 1970 Oct;45(243):717–720. [PMC free article] [PubMed]

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